Retrospective Study of Interstitial Lung Disease in a Tertiary Care Centre in India
Tiyas Sen, Zarir F. Udwadia
Citation Information :
Sen T, Udwadia ZF. Retrospective Study of Interstitial Lung Disease in a Tertiary Care Centre in India. Indian J Chest Dis Allied Sci 2010; 52 (4):207-211.
Background. There has been a recent surge in the recognition of interstitial lung disease (ILD) in India.
Methods. We conducted a retrospective study based on the available medical records of 274 patients with biopsy proven ILD seen during the period 1994-2001 at our tertiary care referral hospital.
Results. Idiopathic pulmonary fibrosis (43%), sarcoidosis (22%), ILDs secondary to collagen vascular disease (19%) and extrinsic allergic alveolitis, among others, were the most common aetiological causes of ILD. The diagnostic yield from transbronchial lung biopsy (TBLB) was high (96%).
Conclusions. Interstitial lung diseases (ILDs) appear to be under-reported from India. Lack of recognition and inadequate availability of diagnostic facilities, like high resolution computed tomography (HRCT) of the chest may be some of the reasons for this. The diagnostic yield from TBLB in our study was high at 96 percent. The TBLB may be used as the initial, cost-effective and safe tool for confirmation of aetiological diagnosis in most patients with diffuse parenchymal lung diseases.
Jindal SK, Malik SK, Deodhar SD, Sharma BK. Fibrosing alveolitis:a report of 61 cases seen over the past five years. Indian J Chest Dis Allied Sci 1979;21:174-9.
Gupta D, Behra D, Joshi K, Jindal SK. Role of fiberoptic bronchoscopy (transbronchial lung biopsy) in diagnosis of parenchymal lung disease. J Assoc Physicians India 1997;45:371-3.
Thiruvengadam KV, Chandrasekaran AN, Kulandaivelu V, Inbavazhvu MN, Venkatramani K. Pleuro pulmonary manifestations of rheumatoid arthritis. Indian J Chest Dis Allied Sci 1979;21:35-52.
Grenier P, Chevret S, Beigelman C, Brauner MW, Chastang C, Valeyre D. Chronic diffuse infiltrative lung disease: determination of the diagnostic value of clinical data, chest radiography, and CT and Bayesian analysis. Radiology 1994;191:383-90.
Joint statement of the American Thoracic Society (ATS) and the European Respiratory Society (ERS). ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2002;165:277-304.
Sen T, Udwadia ZF. Cryptogenic organizing pneumonia: clinical profile in a series of 34 admitted patients in a hospital in India. J Assoc Physicians India 2007;56:229-32.
Shah SS, Tsang V, Goldstraw P. Open lung biopsy: a safe reliable and accurate method for diagnosis in diffuse lung disease. Respiration 1992;59:243-6.
Venn GE, Kay PH, Midwood CJ, Goldstraw PJ. Open biopsy in patients with diffuse pulmonary shadowing. Thorax 1985;40:931-5.
Bensaid DD, MMeIntyre RC Jr, Waring BJ, Simon JS. Comparison of videothoracic lung biopsy to open lung biopsy in the diagnosis of interstitial lung disease. Chest 1993;103:765-70.
Canocham FM, Walker WS, Cameron EWJ. Efficacy of video assisted thoracoscopic lung biopsy: an historical comparison with lung biopsy. Thorax 1994;49:361-3.