The Indian Journal of Chest Diseases and Allied Sciences

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VOLUME 52 , ISSUE 4 ( October-December, 2010 ) > List of Articles

CASE REPORT

Primary Carcinoid of Posterior Mediastinum: Truth or Myth!

Sunil Joshi, Arunkumar Haridas, Priti Lata Rout

Citation Information : Joshi S, Haridas A, Rout PL. Primary Carcinoid of Posterior Mediastinum: Truth or Myth!. Indian J Chest Dis Allied Sci 2010; 52 (4):241-243.

DOI: 10.5005/ijcdas-52-4-241

License: NA

Published Online: 10-12-2010

Copyright Statement:  NA


Abstract

Mediastinal masses present challenging problems in thoracic practice. Most of them remain asymptomatic for long and by the time the pressure symptoms develop, these are quite advanced. Carcinoids arising from the mediastinum are invariably related to thymus. Non-thymic origin of mediastinal carcinoids is rare, especially in the posterior mediastinum. Only two cases of posterior mediastinal carcinoids have been reported so far. These were assumed to be arising from ectopic thymus tissue. We report a case of a 45-year-old woman who presented with dyspnoea and dry cough due to giant carcinoid tumour of the mediastinum, the pedicle originating from the posterior mediastinum, not related to thymus. She underwent thoracotomy and resection that provided relief. The immunochemical studies revealed positive reaction to cytokeratin, chromogranins and synaptophysin, and negative reaction to S100, CD99 (MIC2) confirming the tumour being neuroendocrine in nature.


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  1. Rosai J, Higa E. Mediastinal endocrine neoplasm of probable thymic origin related to carcinoid tumour: clinicopathologic study of 8 cases. Cancer 1972;29:1061-74.
  2. Moran CA, Suster S. Neuroendocrine carcinomas (carcinoid tumor) of the thymus: a clinicopathologic analysis of 80 cases. Am J Clin Pathol 2000;114:100-10.
  3. Cardillo G, Treggiari S, Paul MA, De Massimi AR, Remotti D, Graziano P, et al. Primary neuroendocrine tumours of the thymus: a clinicopathologic and prognostic study in 19 patients Eur J Cardiothorac Surg 2010;37:814-8.
  4. Horie Y, Kato M. Neuroendocrine carcinoma of the posterior mediastinum, a possible primary lesion. Arch Pathol Lab Med 1999;123:933-6.
  5. Barnardo DE, Stavrou M, Bourne R, Bogomoletz WV. Primary carcinoid tumor of the mesentery. Human Pathol 1984;15:796-8.
  6. Horenstein MG, Erlandson R, Gonzalez-Cueto D, Rosai J. Presacral carcinoid tumors: report of three cases and review of the literature. Am J Surg Pathol 1998;22:251-5.
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