The Indian Journal of Chest Diseases and Allied Sciences

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VOLUME 53 , ISSUE 1 ( January-March, 2011 ) > List of Articles


Diagnostic Dilemma of Antineutrophil Cytoplasmic Antibody Seropositivity in Human Immunodeficiency Virus Infection

Naveen Dutt, Ashok K. Janmeja

Keywords : Wegener's granulomatosis, HIV, ANCA, Radiology

Citation Information : Dutt N, Janmeja AK. Diagnostic Dilemma of Antineutrophil Cytoplasmic Antibody Seropositivity in Human Immunodeficiency Virus Infection. Indian J Chest Dis Allied Sci 2011; 53 (1):55-58.

DOI: 10.5005/ijcdas-53-1-55

License: CC BY-NC 4.0

Published Online: 10-06-2022

Copyright Statement:  Copyright © 2011; The Author(s).


We present a case of a 48-year-old male who was diagnosed and treated for Wegener's granulomatosis on the basis of history, clinical features, computed tomography (CT) and antineutrophil cytoplasmic antibodies (ANCA) positivity. The patient initially improved and later on during course of the disease he was found to be human immunodeficiency virus (HIV) seropositive. The potential pitfalls of cANCA in a HIV-infected patient are discussed.

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  1. Hagen EC, Daha MR, Hermans J, Andrassy K, Csernok E, Gaskin G, et al. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR Project for ANCA Assay Standardization. Kidney Int 1998;53:743-53.
  2. Jennette JC, Wilkman AS, Falk RJ. Diagnostic predictive value of ANCA serology. Kidney Int 1998;53:796-8.
  3. Savige JA, Chang L, Crowe SM. Anti-neutrophil cytoplasm antibodies in HIV infection. Adv Exp Med Biol 1993;336:349-52.
  4. Cornely OA, Hauschild S, Weise C, Csernok E, Gross WL, Salzberger B, et al. Seroprevalence and disease association of antineutrophil cytoplasmic autoantibodies and antigens in HIV infection. Infection 1999;27:92-6.
  5. Koderisch J, Andrassy K, Rasmussen N, Hartmann M, Tilgen W. “False-Positive” anti-neutrophil cytoplasmic antibodies in HIV infection. Lancet 1990;335:1227-8.
  6. Habegger de Sorrentino A, Motta P, Iliovich E, Sorrentino AP. [Anti-neutrophil cytoplasmic antibodies (ANCA) in patients with symptomatic and asymptomatic HIV infection]. Medicina (B Aires) 1997;57:294-8.
  7. Otedo AE, Oyoo GO, Obondi JO, Otieno CF. Vasculitis in HIV: report of eight cases. East Afr Med J 2005;82:656-9.
  8. Garcia-Garcia JA, Macias J, Castellanos V, Fernandez- Rivera J, Lozano-Gutierrez F, Rivera JM, et al. Necrotizing granulomatous vasculitis in advanced HIV infection. J Infect 2003;47:333-5.
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