Citation Information :
Agarwal S, Gupta K, Mullick S, Chauhan A, Dewan R. Pulmonary Tumourlets: Case Report and Review of Literature. Indian J Chest Dis Allied Sci 2015; 57 (4):235-238.
We report a case of tumourlets of the lung associated with carcinoid and neuroendocrine cell hyperplasia, found incidentally in a 30-year-old woman, who underwent bullectomy for pneumothorax. These lesions are histologically similar to carcinoid, but differ in molecular pathogenesis about which little is known. Their nature and significance is debated. Here, we point out the importance of histological, clinical, and diagnostic aspects and follow-up to have evidence of eventual malignant evolution.
Sheerin N, Harrison NK, Sheppard MN, Hansell DM, Yacoub M, Clark TJH. Obliterative brochiolitis caused by multiple tumorlets and microcarcinoids successfully treated by single lung transplantation. Thorax 1995;50:207–9.
He P, GuX, Wu Q, Lin y, Gu Y, He J. Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis. J Thorac Dis 2012;4:655–8.
Finkelstein SD, Hasegawa T, Colby T, Yousem SA. 11q13 allelic imbalance discriminates pulmonary carcinoids from tumorlets. Am J Pathol 1999;155:633–40.
Rekhtman N. Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med 2010;134:1628–38.
Klinke F, Bosse U, Hofler H. The tumorlet carcinoid in bronchiectasis-changed lungs: an example of a multifocal, endocrine tumor. Pnemologic 1990;44:607–9.
Churg A, Warnock ML. Pulmonary tumourlet: a form of peripheral carcinoid. Cancer 1976;37:1469–77.
Aubry MC, Thomas CF Jr, Jett JR, Swensen SJ, Myers JL. Significance of multiple carcinoid tumors and tumorlets in surgical lung specimens: analysis of 28 patients. Chest 2007;131:1635–43.
Joseph F, Tomashefski JF, Dail DH. Aspiration, bronchial obstruction, bronchiectasis and related disorders. In: Tomashefski JF, editors Dail and Hammer's Pulmonary Pathology; 3rd edition. New York: Springer; 2008: pp 84–132.
Yuitch F, Sekido Y, Fong K, Mackay B, Minna JD, Gazdar AF. Neuroendocrine tumors of the lung: pathology and molecular biology. Chest Surg Clin North Am 1997;7:21–47.
D'Agati VD, Perzin KH. Carcinoid tumorlets of the lung with metastasis to a peribronchial lymphnode: report of a case and review of the literature. Cancer 1985;55:2472–6.
Ginsberg MS, Akin O, Berger DM, Zakowski MF, Panicek DM. Pulmonary tumorlets: CT findings. AJR Am J Roentgenol 2004;183:293–6.
Morita H, Sakai S, Miyajima N, Murakami T, Yamakawa T, Mizuguchi K. A case of lung tumorlets with pulmonary carcinoid. Japenese J Thoracic Surg 2000;53:969–1.