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VOLUME 57 , ISSUE 4 ( October-December, 2015 ) > List of Articles


Mediastinal Gray Zone Lymphoma

Mukesh Bhardwaj, Rajat Saha, Deepti Shukla Misra, Veena Malhotra

Keywords : Mediastinal gray zone lymphoma, Non-Hodgkin's large B-cell lymphoma, Hodgkin's lymphoma, Overlapping features

Citation Information : Bhardwaj M, Saha R, Misra DS, Malhotra V. Mediastinal Gray Zone Lymphoma. Indian J Chest Dis Allied Sci 2015; 57 (4):255-257.

DOI: 10.5005/ijcdas-57-4-255

License: CC BY-NC 4.0

Published Online: 18-11-2022

Copyright Statement:  Copyright © 2015; The Author(s).


A 50-year-old male presented with cough and breathlessness. A positron emissoin tomography scan revealed FDG (Fluorodeoxyglucose) avid mediastinal mass. Tru-cut biopsy showed fibrotic stromal tissue with cellular infiltrate consisting of abnormal lymphoid cells and few large cells with smudged nucleus. Immunohistochemistry revealed diffuse positivity with CD20, focal positivity for CD30 and rare CD15 positive cells. Histological picture and immune profile showed overlaping features of non-Hodgkin's as well as Hodgkin's lymphoma. A diagnosis of mediastinal gray zone lymphoma was made. The patient showed a complete metabolic response to six cycles of chemotherapy.

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