The Indian Journal of Chest Diseases and Allied Sciences

Register      Login

VOLUME 58 , ISSUE 1 ( January-March, 2016 ) > List of Articles

CASE REPORT

Spectrum of Clinical Presentation of Pulmonary Alveolar Microlithiasis: Case Series from North India

Surender Kashyap, P.R. Mohapatra, Anjali Solanki, R.S. Negi, Malay Sarkar

Keywords : Microlithiasis, Sand-storm lung, Pericardial calcification

Citation Information : Kashyap S, Mohapatra P, Solanki A, Negi R, Sarkar M. Spectrum of Clinical Presentation of Pulmonary Alveolar Microlithiasis: Case Series from North India. Indian J Chest Dis Allied Sci 2016; 58 (1):39-43.

DOI: 10.5005/ijcdas-58-1-39

License: CC BY-NC 4.0

Published Online: 17-11-2022

Copyright Statement:  Copyright © 2016; The Author(s).


Abstract

We describe five cases of pulmonary alveolar microlithiasis (PAM) from North India with characteristic radiological and histopathological features. All patients were symptomatic with variable severity and duration of the symptoms and one patient developed cor-pulmonale during the course of follow-up. Diagnosis of PAM was suspected on the basis of classical sand-storm appearance on radiological examination and confirmed by transbronchial lung biopsy in four of the five cases. Apart from other features, presence of pleural and pericardial calcification in one case makes this discussion valuable. Awareness of this specific entity among the clinicians is essential to avoid unnecessary investigations.


PDF Share
  1. Harbitz E. Extensive calcification of the lungs as a distinct disease. Arch Intern Med 1918;21:139–46.
  2. Puhr L. Microlithiasis alveolaris pulmonum. Virchows Arch Pathol Anat 1993;290:156–60.
  3. Kashyap S, Mohapatra PR. Pulmonary alveolar microlithiasis. Lung India 2013;30:143–7.
  4. Viswanathan R. Pulmonary alveolar microlithiasis. Thorax 1962;17:251–6.
  5. Gayathri Devi HJ, Mohan Rao KN, Prathima KM, Das JK. Pulmonary alveolar microlithiasis. Lung India 2011;28:139–41.
  6. Chandra S, Mohan A, Guleria R, Das P, Sarkar C. Bilateral stony lung: pulmonary alveolar microlithiasis. BMJ Case Rep 2009;1012.
  7. Hira HS, Singh T, Chowdhary V. Pulmonary alveolar microlithiasis: role of transbronchial lung biopsy. J Assoc Physicians India 2000;48:832–3.
  8. Malhotra B, Sabharwal R, Singh M, Singh A. Pulmonary alveolar microlithiasis with calcified pleural plaques. Lung India 2010;27:250–2.
  9. Singh NK, Gupta A. Pulmonary alveolar microlithiasis. J Assoc Physicians India 1995;43:647–8.
  10. Kashyap S, Kumar M, Pal LS. Pulmonary alveolar microlithiasis in a Himachali woman. J Assoc Physicians India 1996;44:56–7.
  11. Ucan ES, Keyf AI, Aydilek R, Yalcin Z, Sebit S, Kudu M, et al. Pulmonary alveolar microlithiasis: review of Turkish reports. Thorax 1993;48:171–3.
  12. Mariotta S, Ricci A, Papale M, De Clementi F, Sposato B, Guidi L, et al. Pulmonary alveolar microlithiasis: report on 576 cases published in the literature. Sarcoidosis Vasc Diffuse Lung Dis 2004;21:173–81.
  13. Castellana G, Lamorgese V. Pulmonary alveolar microlithiasis: world cases and review of the literature. Respiration 2003;70:549– 55.
  14. Lopez-Areal L, Zumarraga R, Gil Turner C, Martin Granizo IF, Vara Cuadrado F, Duque Fraile J. Infantile familial pulmonary alveolar microlithiasis: description of 5 cases in 2 families. Rev Clin Esp 1965;97:389–95.
  15. Edelman JD, Ravaria J, Kaiser LR, Litzky LA, Palevsky HI, Kotloff RM. Bilateral sequential lung transplantation for pulmonary alveolar microlithiasis. Chest 1997;112:1140–44.
  16. Huqun, Izumi S, Miyazawa H, Ishii K, Uchiyama B, Ishida T, et al. Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med 2007;175:263–8.
  17. Hashimoto M, Wang DY, Kamo T, Zhu Y, Tsujiuchi T, Konishi Y, et al. Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung. Am J Pathol 2000;157:21–7.
  18. Tachibanaa T, Hagiwarab K, Johkoh T. Pulmonary alveolar microlithiasis: review and management. Cur Opin Pulmon Med 2009;15:486–90.
  19. Moran CA, Hochholzer L, Hasleton PS, Johnson FB, Koss MN. Pulmonary alveolar microlithiasis: a clinicopathologic and chemical analysis of seven cases. Arch Pathol Lab Med 1997;121:607–11.
  20. Prakash UB, Barham SS, Rosenow EC 3rd, Brown ML, Payne WS. Pulmonary alveolar microlithiasis: a review including ultrastructural and pulmonary function studies. Mayo Clin Proc 1983;58:290–300.
  21. Mascie-Taylor BH, Wardman AG, Madden CA, Page RL. A case of alveolar microlithiasis: observation over 22 years and recovery of material by lavage. Thorax 1985;40:952–3.
  22. Sumikawa H, Johkoh T, Tomiyama N, Hamada S, Koyama M, Tsubamoto M, et al. Pulmonary alveolar microlithiasis: CT and pathologic findings in 10 patients. Monaldi Arch Chest Dis 2005;63:59–64.
  23. Deniz O, Ors F, Tozkoparan E, Ozcan A, Gumus S, Bozlar U, et al. High resolution computed tomographic features of pulmonary alveolar microlithiasis. Eur J Radiol 2005;55:452–60.
  24. Hoshino H, Koba H, Inomata S, Kurokawa K, Morita Y, Yoshida K, et al. Pulmonary alveolar microlithiasis: highresolution CT and MR findings. J Comput Assist Tomogr 1998;22:245–8.
  25. Coetzee T. Pulmonary alveolar microlithiasis with involvement of sympathetic nervous system and gonads. Thorax 1970;25:637-42.
  26. Pant K, Shah A, Mathur RK, Chhabra SK, Jain SK. Pulmonary alveolar microlithiasis with pleural calcification and nephrolithiasis. Chest 1990;98:245–6.
  27. Arslan A, Yalin T, Akan H, Belet U. Pulmonary alveolar microlithiasis associated with calcifications in the seminal vesicles. J Belge Radiol 1996;79:118–9.
  28. Palombini BC, da Silva Porto N, Wallau CU, Camargo JJ. Bronchopulmonary lavage in alveolar microlithiasis. Chest 1981;80:242–3.
  29. Mariotta S, Guidi L, Papale M, Ricci A, Bisetti A. Pulmonary alveolar microlithiasis: review of Italian reports. Eur J Epidemiol 1997;13:587–90.
  30. Stamatis G, Zerkowski HR, Doetsch N, Greschuchna D, Konietzko N, Reidemeister JC. Sequential bilateral lung transplantation for pulmonary alveolar microlithiasis. Ann Thorac Surg 1993;56:972–5.
  31. Jackson KB, Modry DL, Halenar J, L'abbe J, Winton TL, Lien DC. Single lung transplantation for pulmonary alveolar microlithiasis. J Heart Lung Transplant 2001;20:226.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.