Comparison of Effect of Levocetirizine or Montelukast Alone and in Combination on Symptoms of Allergic Rhinitis

Swayamsidha Andhale; Harish Chander Goel; Saispoorthi Nayak

doi:10.5005/ijcdas-58-2-103

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Comparison of Effect of Levocetirizine or Montelukast Alone and in Combination on Symptoms of Allergic Rhinitis

Swayamsidha Andhale, Harish Chander Goel, Saispoorthi Nayak

Keywords : Allergic rhinitis, Montelukast, Levocetirizine

Citation Information : Andhale S, Goel HC, Nayak S. Comparison of Effect of Levocetirizine or Montelukast Alone and in Combination on Symptoms of Allergic Rhinitis. Indian J Chest Dis Allied Sci 2016; 58 (2):103-105.

DOI: 10.5005/ijcdas-58-2-103

License: NA

Published Online: 17-06-2016

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Abstract

Objective: To determine the effect of levocetirizine, montelukast and the combination of both the drugs on symptoms of allergic rhinitis. Methods: Seventy-five patients with allergic rhinitis were randomly studied prospectively for a period of two weeks divided into three groups receiving either levocetrizine or montelukast or combination of both. The outcomes were measured by a visual analogue score for nasal and eye symptom during day-time and night-time. Results: All the three regimens were equally effective in improving the day-time symptoms, like sneezing and rhinorrhea. There was also no difference in the control of night-time and eye symptoms among the regimens. Conclusions: Montelukast, levocetirizine and their combination is equally effective in controlling symptoms, of allergic rhinitis. Thus, use of montelukast alone would be cost-effective and do avoid adverse effects of levocetirizine in combination therapy.

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Gupta V, Matreja PS. Efficacy of montelukast and levocetirizine as treatment for allergic rhinitis. J Aller Ther 2010;1:103.
Ciebiada M, Ciebiada MG, Kmieck T, Dubuske LM, Gorski P. Quality of life in patients with perennial allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratidine. J Invest Allergol Clin Immunol 2008;18:343–9.
Kurowski M, Kuna P, Gorski P. Montelukast plus cetirizine in prophylactic treatment of seasonal allergic rhinitis: influence on clinical symptoms and nasal allergic inflammation. Allergy 2002;59:280–8.
Sur DK, Scandale S. Treatment of allergic rhinitis. Am Fam Physician 2010;81:1440–6.
Valet RS, FahrenholzJ M. Allergic rhinitis: update on diagnosis. Consultant 2009;49:610–3.
Bosquet J, van Cauwenberge P, Khaltaev N. ARIA Workshop Group, WHO. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108:S147–334.
Philip G, William-Herman D, Patel P, Weinstein SF, Alon A, Gilles L, et al. Efficacy of montelukast for treating perennial allergic rhinitis. Allergy Asthma Proc 2007;28:296–304.
van Adelsberg J, Philip G, LaForce CF, Weinstein SF, Menten J, Malice MP, et al. Randomised controlled trail evaluating the clinical benefit of montelukast for treating spring seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2003;90:214-22.

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