Background. Diffuse parenchymal lung diseases (DPLDs) represent a group of disorders with overlapping clinical and radiological features. Lung biopsy is usually required to make an aetiological diagnosis of DPLD. Open lung biopsy which is still considered as the gold standard for the diagnosis of DPLDs, is associated with significant mortality and morbidity. Transbronchial lung biopsy (TBLB) through fibreoptic bronchoscope is safe and less invasive method in patients with DPLDs. Objectives. To describe the diagnostic yield and complications of TBLB in patients with DPLD seen at our centre. Methods. We prospectively studied patients with DPLD who underwent TBLB over a 2-year period. Results. A total of 102 patients were enrolled in the study. TBLB confirms a diagnosis in 80 (78.4%) patients. Granulomatous inflammation (30 [37.5%]), non-specific interstitial pneumonia (15 [18.7%]), neoplasia (13 [16.2%]) were the most common histological findings. No procedure-related mortality was observed. Seven (6.8%) patients developed pneumothorax. Major bleeding that requires admission to intensive care unit was reported in 1 (0.9%) patient only. Conclusions. Transbronchial lung biopsy is a safe and useful procedure for diagnosis of DPLDs. The yield of TBLB is high when centrilobular and perilymphatic involvement is found radiologically. At least four to six biopsies per TBLB should be taken to improve the overall yield of TBLB.