The Indian Journal of Chest Diseases and Allied Sciences

Register      Login

VOLUME 59 , ISSUE 1 ( January-March, 2017 ) > List of Articles


A Male with SLE and Familial Hyperhomocysteinemia: A Rare Presentation

Devesh Pratap Singh, Omkar K. Choudhari, Umesh Chandra Ojha

Keywords : Hyperhomocysteinemia, Pulmonary embolism, Systemic lupus erythematosus, Chronic interstitial pneumonia

Citation Information : Singh DP, Choudhari OK, Ojha UC. A Male with SLE and Familial Hyperhomocysteinemia: A Rare Presentation. Indian J Chest Dis Allied Sci 2017; 59 (1):35-37.

DOI: 10.5005/ijcdas-59-1-35

License: CC BY-NC 4.0

Published Online: 18-11-2022

Copyright Statement:  Copyright © 2017; The Author(s).


We report a case of a 45-year-old male patient with sudden onset dyspnoea, cough and streaky haemoptysis. The patient was already being treated with anti-tuberculosis drugs by a general practitioner for suspected tubercular pleural effusion for the last 8 months. Computed tomography-pulmonary angiography revealed pulmonary thrombo-embolism. As patient have high plasma homocysteine values, further work-up of the patient including a detailed history taking, physical and laboratory examination established a diagnosis of systemic lupus erythematosus (SLE). Patient was treated with heparin, vitamin B12 and folic acid supplementation in addition to corticosteroids, along with supportive and symptomatic treatment. However, the progressive course the illness resulted in the development of chronic interstitial pneumonia and he succumbed to the illness.

PDF Share
  1. Ueland PM, Refsum H, Beresford SAA, Vollset SE. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 2000;72:324-32.
  2. Martinez-Berriotxoa A, Ruiz-Irastorza G, Egurbide Arberas MV, Rueda Gutierrez M, Aguirre Errasti C. Plasma homocysteine levels in systemic lupus erythematosus. Med Clin (Barc) 2003;120:681-5.
  3. Petri M. Epidemiology of systemic lupus erythematosus. Best Pract Res Clin Rheumatol 2002;16:847-58.
  4. Beresford MW, Cleary AG, Sills JA, Couriel J, Davidson JE. Cardio-pulmonary involvement in juvenile systemic lupus erythematosus. Lupus 2005;14:152-8.
  5. Todd NW, Wise RA. Respiratory complications in the collagen vascular diseases. Clin Pulm Med 1996;3:101-12.
  6. Orens JB, Martinez FJ, Lynch JP III. Pleuropulmonary manifestations of systemic lupus erythematosus. Rheum Dis Clin North Am 1994;20:159-93.
  7. Yoelekar ME, Shette MM. Homocysteine and hypertension. J Assoc Physicians India 2002;50 (Suppl.):29-35.
  8. Den Heijer M, Koster D, Blom HJ, Bos MJG, Briet E, Reitsma PH, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996;334:759-62.
  9. Yoelekar ME, Shette MM. Treatment of hyper-homocysteinemia and its impact on disease. J Assoc Physicians India 2002;50 (Suppl.):43-46.
  10. Haupt HM, Moore GW, Hutchins GM. The lung in systemic lupus erythematosus: analysis of the pathologic changes in 120 patients. Am J Med 1981;71:791-98.
  11. Weinrib L, Sharma OP, Quismorio FP Jr. A long-term study of interstitial lung disease in systemic lupus erythematosus. Semin Arthritis Rheum 1990;20:48-56.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.