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VOLUME 59 , ISSUE 2 ( April-June, 2017 ) > List of Articles

Original Article

Pulmonary Rehabilitation in Patients with Interstitial Lung Diseases in an Outpatient Setting: A Randomised Controlled Trial

Vivek KU, Ashok Kumar Janmeja, Deepak Aggarwal, Parul Sood

Keywords : Interstitial lung disease, Pulmonary rehabilitation, Six-minute walk test

Citation Information : KU V, Janmeja AK, Aggarwal D, Sood P. Pulmonary Rehabilitation in Patients with Interstitial Lung Diseases in an Outpatient Setting: A Randomised Controlled Trial. Indian J Chest Dis Allied Sci 2017; 59 (2):75-80.

DOI: 10.5005/ijcdas-59-2-75

License: NA

Published Online: 18-06-2017

Copyright Statement:  NA


Abstract

Background. Interstitial lung diseases (ILDs) are a group of progressive diseases with few effective treatments. Pulmonary rehabilitation is a non-pharmacological intervention with a proven role in COPD. However, there is limited evidence on its usefulness in patients with ILDs. Objectives. This study was planned to assess the effect of pulmonary rehabilitation on exercise capacity and healthrelated quality-of-life (HRQoL) in patients with ILD. Methods. Forty patients with stable ILDs were randomised to receive either conventional treatment (control group) or standard treatment plus pulmonary rehabilitation programme for 8 weeks (study group). Exercise capacity was assessed by six-minute walk test (6MWT) and QoL was measured by St George's Respiratory Questionnaire (SGRQ) at baseline and at the end of 8 weeks. Results. At the end of 8 weeks, there was a statistically significant improvement in 6MWT distance (mean increase of 23.8 meters; p=0.037) and a significant decline in the SGRQ score (by 8.8 units; p=0.003) in the study group as compared to the control group. Conclusion. Pulmonary rehabilitation improves exercise capacity and HRQoL in patients with stable ILDs.


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  1. Coultas DB, Zumwalt RE, Black WC, Sobonya RE. The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med 1994;150:967-72.
  2. Egan JJ. New treatments for pulmonary fibrosis? Lancet 1999;354:1839-40.
  3. King TE Jr, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, et al. A phase 3 trial of perfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med 2014;370:2083-92.
  4. Collard HR, King TE Jr, Bartelson BB, Vourlekis JS, Schwarz MI, Brown KK, et al. Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003;168:538-42.
  5. Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, et al. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med 2006;173:1390-413.
  6. Harris-Eze AO, Sridhar G, Clemens RE, Zintel TA, Gallagher CG, Marciniuk DD. Role of hypoxemia and pulmonary mechanics in exercise limitation in interstitial lung disease. Am J Respir Crit Care Med 1996;154:994-1001.
  7. Lacasse Y, Goldstein R, Lasserson TJ, Martin S. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006:CD003793.
  8. Laviolette L, Bourbeau J, Bernard S, Lacasse Y, Pepin V, Breton MJ, et al. Assessing the impact of pulmonary rehabilitation on functional status in COPD. Thorax 2008;63:115-21.
  9. Holland AE, Hill CJ, Conron M, Munro P, McDonald CF. Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease. Thorax 2008;63:549-54.
  10. Ferreira A, Garvey C, Connors GL, Hilling L, Rigler J, Farrell S, et al. Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of response. Chest 2009;135:442-7.
  11. Bradley B, Branley HM, Egan JJ, Greaves MS, Hansell DM, Harrison NK, et al. Interstitial lung disease guidelines: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax 2008;63(Suppl. 5):v1-58.
  12. Nishiyama O, Kondoh Y, Kimura T, Kato K, Kataoka K, Ogawa T, et al. Effects of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis. Respirology 2008;13:394-9.
  13. American Thoracic Society. Standardisation of spirometery 1994 update. Am J Respir Crit Care Med 1995;152:1107-36.
  14. Fletcher CM. The clinical diagnosis of pulmonary emphysema: an experimental study. Proc R Soc Med 1952;45:577-84.
  15. Barr JT, Schumacher GE, Freeman S, LeMoine M, Bakst AW, Jones PW. American translation, modification, and validation of the St. George's Respiratory Questionnaire. Clin Ther 2000;22:1121-45.
  16. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS Statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166:111-7.
  17. Huppmann P, Sczepanski B, Boensch M, Winterkamp S, Schönheit-Kenn U, Neurohr C, et al. Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease. Eur Respir J 2013;42:444-53.
  18. Swigris JJ, Fairclough DL, Morrison M, Make B, Kozora E, Brown KK, et al. Benefits of pulmonary rehabilitation in idiopathic pulmonary fibrosis. Respir Care 2011;56:783-9.
  19. Kozu R, Senjyu H, Jenkins SC, Mukae H, Sakamoto N, Kohno S. Differences in response to pulmonary rehabilitation in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Respiration 2011;81:196-205.
  20. Ozalevli S, Karaali HK, Ilgin D, Ucan ES. Effect of homebased pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis. Multidiscip Respir Med 2010;5:31-7.
  21. Dowman L, Hill CJ, Holland AE. Pulmonary rehabilitation for interstitial lung disease. Cochrane Database Syst Rev 2014 Oct 6;10:CD006322.
  22. Kozu R, Jenkins S, Senjyu H. Effect of disability level on response to pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis. Respirology 2011;16:1196-202.
  23. Jones PW. St. George's Respiratory Questionnaire: MCID. COPD 2005;2:75-9.
  24. Jastrzebski D, Gumola A, Gawlik R, Kozielski J. Dyspnea and quality of life in patients with pulmonary fibrosis after six weeks of respiratory rehabilitation. J Physiol Pharmacol 2006;57(Suppl. 4):139-48.
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