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VOLUME 60 , ISSUE 2 ( April-June, 2018 ) > List of Articles

Original Article

A Prospective Study of Clinical Characteristics of Patients with Sarcoidosis from Punjab

Akashdeep Singh, Sandeep Puri, Kavita Saggar, Neena Sood

Keywords : Sarcoidosis, Ethnicity, Clinical, Punjabi, Pulmonary

Citation Information : Singh A, Puri S, Saggar K, Sood N. A Prospective Study of Clinical Characteristics of Patients with Sarcoidosis from Punjab. Indian J Chest Dis Allied Sci 2018; 60 (2):61-68.

DOI: 10.5005/ijcdas-60-2-61

License: CC BY-NC 4.0

Published Online: 18-11-2022

Copyright Statement:  Copyright © 2018; The Author(s).


Background and objectives: There is wide variation in clinical presentations of sarcoidosis across different ethnic groups and geographical areas. Methods: Ninety-six patients with histopathologically proven sarcoidosis from Punjab were studied during the period January 2012 to January 2016 at the teaching hospital attached to our medical college. Results: Their mean age was 46.6±10.6 years; there were 51 (53.1%) females. All the patients were symptomatic at the time of presentation; 64.6% presented with predominantly respiratory symptoms while 35.4% had prominent extra-pulmonary symptoms. The various extra-pulmonary features presenting as the initial manifestations of sarcoidosis in the present study included prolonged pyrexia (13.5%); acute kidney injury (5.2%); neurological (5.2%); salivary gland (5.2%) and ocular (3.1%) involvement. About 10% of our patients had presented with life threatening manifestations as the sole presentation of the disease. The chest radiograph at presentation revealed stage 0 in 5.2%; stage 1 in 51.1%; stage 2 in 26% and stage 3 in 17.7% patients. Conclusions: In our study female preponderance was noted and the disease peaked during the late fourth decade of life. All the patients were symptomatic at the time of presentation and extra-pulmonary manifestations were the presenting feature in around one-third of the patients. Prolonged pyrexia, anicteric cholestasis, salivary gland involvement and AKI were uncommon, but important salient clinical manifestations in patients presenting with sarcoidosis from Punjab.

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