Citation Information :
Sahu D, Chandermani, Jain P. Can Chronic Obstructive Pulmonary Disease be Associated with Arterial Stiffness?: A Case-control Multi-group Study. Indian J Chest Dis Allied Sci 2018; 60 (2):69-75.
Background: Researchers have linked chronic obstructive pulmonary disease (COPD) to potential mechanisms increasing arterial stiffness. However, clinically the presence of COPD as risk factor for cardiovascular diseases is still unclear. The present study is aimed at assessing the COPD have an association with the risk of increased arterial stiffness.
Methods: This hospital-based, multi-group, case-control study comprised of three groups of patients: Group I: 50 COPD patients; Group II: 50 non-COPD smokers; and Group III: 50 normal healthy individuals who were nonsmokers. Arterial stiffness of study subjects were measured by using non-invasive volume plethysmographic apparatus periscope.
Results: The mean brachio-ankle pulse wave velocity (baPWV) (cm/s) of COPD patients was found to be higher in comparison to healthy non-smokers (1696.4±341.3 versus 1405.4±622.7; p=0.005). The mean carotid femoral PWV was also significantly higher among COPD patients compared to control group (1197.7±273.5 versus 857.8±175.0; p<0.001). A weak negative correlation was found between forced expiratory volume in one second and baPWV among COPD patients (r=-0.024; p=0.871), however, for Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3&4 patients it was statistically significant (r=-0.450;p=0.016).
Conclusion: Chronic obstructive pulmonary disease have no significant association with cardiovascular diseases independently, though in advance stage it can be consider as a strong predictor of increase in arterial stiffness.
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