Citation Information :
Chaitanya PS, Suresh V, Mohan A, Sachan A, Divya BS, Raghavendra K, Manideepti D. Pulmonary Function in Hypothyroidism Before and After Restoration of Euthyroid Status. Indian J Chest Dis Allied Sci 2020; 62 (2):51-56.
Objective: Pulmonary manifestations are rarely a major problem in hypothyroid patients; though subtle restrictive pattern on spirometry has been reported. The effect of thyroxine replacement on spirometric indices has not been adequately studied.
Methods: Patients with primary hypothyroidism (thyroid stimulating hormone [TSH] > 15 mIU/L) not having any known pulmonary or cardiac pathological (N=42) were screened for inclusion in the study. All patients underwent spirometry and following parameters were recorded: forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, mid-expiratory flow rate (FEV25%-75%), peak expiratory flow rate (PEFR), both as absolute values and as a percentage of the predicted value. Subsequently, patients were started on levothyroxine replacement treatment and the dosage was titrated to achieve euthyroid state. Spirometry was repeated two months or more after the restoration of the euthyroid state.
Results: Their mean age was 37.1±12.6 years. No significant correlation was observed between thyroxine (T4) and thyroid stimulating hormone (TSH) and any of the baseline spirometric parameters. Comparison of spirometric parameters (as percentage of predicted values) before and after treatment showed a clinically significant improvement in FVC, FEV1 and FEF25%-75% (P< 0.05).
Conclusions: Hypothyroidism was characterised by an asymptomatic; yet predominant restrictive pattern of pulmonary function abnormality. After thyroxine replacement, there was a significant improvement in the restrictive pattern.
Fuping Guo MD, Tengda Xu MD, Houli Wang MD. Early recognition of myxedematous respiratory failure in elderly. Am J Emerg Med 2009;27:212–5.
Rajagopal KR, Abbrecht PH, Derderian SS, Pickett C, Hofeldt F, Tellis CJ, et al. Obstructive sleep apnoea in hypothyroidism. Ann Intern Med 1984;101:491–4.
Landenson PW, Goldenheim PD, Ridgway EC. Prediction and reversal of blunted ventilatory responsiveness in patients with hypothyroidism. Am J Med 1988;84:877–83.
Martinez FJ, Bermudez-Gomez M, Celli BR. Hypothyroidism: a reversible cause of diaphragmatic dysfunction. Chest 1989;96:1059–63.
Cakmak G, Saler T, Salgam Z, Yenizen M, Demir T. Spirometry in patients with clinical and subclinical hypothyroidism. Tuberk Toraks 2007;55:266–70.
Maiti SR, Maiti A, Bose I, Chakraborti D, Ghosh P, Dutta AN. Study of pulmonary function tests in patients of primary hypothyroidism. Indian J Basic Appl Med Res 2015;15:121–7.
Roel S, Punyabati O, Prasad L, Salam R, Ningshen K, Shimray AJ, et al. Assessment of functional lung impairment in hypothyroidism. IOSR J Dent Med Sci 2014;13:4–7.
Bhuvaneswari T. Evaluation of pulmonary function in patients with hypothyroidism who are on conservative management. Sch J App Med Sci 2014;2:495–7.
Mohan A, Premanand R, Reddy LN, Rao MH, Sharma SK, Kamity R, et al. Clinical presentation and predictors of outcome in patients with severe acute exacerbation of chronic obstructive pulmonary disease requiring admission to intensive care unit. BMC Pulm Med 2006;6:27.
Suresh V, Reddy A, Mohan A, Rajgopal G, Satish P, Harinarayan C, et al. High prevalence of spirometric abnormalities in patients with type 1 diabetes mellitus. Pediatr Endocrinol Diabetes Metab 2011;17:71–5.
American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991;144:1202–18.
Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, et al. Interpretative strategies for lung function tests. Eur Respir J 2005;26:948–68.
Udovic M, Pena RH, Patham B, Tabatabai L, Kansara A. Hypothyroidism and the heart. Methodist DeBakey Cardiovasc J 2017;13:55-59.
Wood-Allum CA, Shaw PJ. Thyroid disease and the nervous system. Handb Clin Neurol 2014;120:703-35.
Ali ER. Assessment of functional lung impairment in patients with thyroid disorders. Egypt J Bronchol 2016;103:37–47.
Siafakas NM, Salesiotou V, Filaditaki V, Tzanakis N, Thalassinos N, Bouros D. Respiratory muscle strength in hypothyroidism. Chest 1992;102:189–94.
Bassi R, Dhillon SK, Sharma S, Sharma A, Tapdiya M. Effect of thyroid hormone replacement on respiratory function tests in hypothyroid women. Pakistan J Physiol 2012;8:20–4.
Sharifi F, Amari A. Effect of levothyroxine on pulmonary function tests of hypothyroid patients. Int J Endocrinol Metab 2005;1:48–51.
Whybrow PC, Prange AJ, Treadway CR. Mental changes accompanying thyroid gland dysfunction: a reappraisal using objective psychological measurement. Arch Gen Psychiat 1969;20:48.63.
Kelderman-Bolk N, Visser TJ, Tijssen JP, Berghout A. Quality of life in patients with primary hypothyroidism related to BMI. Eur J Endocrinol 2015;173:507.15.
Osterweil D, Syndulko K, Cohen SN, Pettier-Jennings PD, Hershman JM, Cummings JL, et al. Cognitive function in non-demented older adults with hypothyroidism. J Am Geriatr Soc 1992;40:325.35.
Douglass RC, Jacobson SD. Pathologic changes in adult myxedema: survey of 10 necropsies. J Clin Endocrinol Metab 1957;17:1354.64.
Hundertmark S, Ragosch V, Zimmermann B, Halis G, Arabin B, Weitzel HK. Effect of dexamethasone, triiodothyronine and dimethyl-isopropyl-thyronine on lung maturation of the fetal rat lung. J Perinat Med 1999;27:309.15.