Objectives: Multiple factors affect quality-of-life (QoL) in patients with chronic obstructive pulmonary disease (COPD). The study was done to explore possible factors which influence disease specific QoL in patients with COPD.
Methods: A cross-sectional study was carried out at our tertiary care hospital. Patients above 40 years of age, Global Initiative for Chronic Obstructive Lung Diseases (GOLD) category I-IV, irrespective of tobacco smoking status with disease duration of five years or more were included. Patients with other chronic respiratory diseases, co-morbid conditions and functional limitations, psychiatric or cognitive problems were excluded. Demographic factors, lifestyle and disease severity parameters; physical, physiological and mental factors were recorded. St. George's Respiratory Questionnaire-C (SGRQ-C) scores were used to assess the QoL. Correlation coefficient, bivariate analysis and multiple linear regression analysis were done.
Results: A total of 78 patients with a mean age of 61.6 years and male preponderance were enrolled. The mean six-minute walk distance (6MWD) test was 235.5 meters. Seventy-three patients were suffering from depression, 67 patients had anxiety and 71 had sleep disturbances. The mean SGRQ-C score was 45.4±14.7. On bivariate analysis, 6MWD, modified Medical Research Council (mMRC) dyspnoea score, depression, anxiety, and sleep disturbances were significantly correlated with the QoL scores (P<0.01). Linear regression analysis showed that 6MWD and sleep disturbance significantly correlated with QoL scores.
Conclusion: Results of the present study showed that functional capacity as measured by 6MWD and sleep disturbances were the two strongly correlated factors associated with QoL in patients with COPD.
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