Citation Information :
Kumar R, Mavi AK, Singh K, Kumar M. Correlation of hs-CRP, Exhaled Nitric Oxide and Atopic Status in Non-Obese and Obese Bronchial Asthma Patients. Indian J Chest Dis Allied Sci 2021; 63 (1):7-12.
Objectives: Obesity and asthma are the common conditions that describe the distinctive nature of inflammation. The high-sensitivity C-reactive protein (hs-CRP) and fraction of exhaled nitric oxide (FENO) levels are known to influence the atopic status. This study was undertaken to compare these inflammatory markers and atopic profile between non-obese and obese asthmatic patients.
Methods: Two hundred asthma patients aged between 11-58 years were enrolled for this study and divided into two groups: non-obese [body mass index (BMI) <25 kg/m2) (n=100) and obese (BMI>30 kg/m2) (n=100)]. All the subjects were assessed for the pulmonary function test (PFT), hs-CRP from blood serum, FENO and skin prick test (SPT) against the battery of 58 common aero-allergens and subjects having at least one SPT positive were labelled as atopics.
Results: Of these 200 patients, 135 (67.5%) were atopics [n=80 (59.3%) non-obese; and n=55 (40.7%) obese]. The BMI for the non-obese and obese group was 22.4 and 33.9 Kg/m2, respectively. The functional residual capacity percent (FRC%) of non-obese and obese were (111.2±24.6 versus 88.54±19.99 (P<0.001) and expiratory reserve volume (ERV%) predicted was (97.750±33.571 versus 70.9±24.8; P<0.001). Both FRC% and ERV% were significantly lower in the obese group. Levels of FENO of non-obese were significantly higher than the obese (38.08±3.13 versus 30.77±3.02; P=0.0685). The hs-CRP was significantly higher in obese atopics in comparison to non-obese (15.33±23.66 versus 21.60±45.35; P<0.001).
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