Citation Information :
Gupta K, Tandon A, Ghalaut V, Kumar V, Alok Y. Evaluation of Effect of Category I Anti-Tuberculosis Therapy on Vitamin D Status of Pulmonary Tuberculosis Patients: A Single Centre, Prospective, Observational Study. Indian J Chest Dis Allied Sci 2021; 63 (1):13-16.
Objective: Tuberculosis (TB) is a significant cause of mortality and morbidity worldwide. Vitamin D deficiency has been implicated to cause pulmonary TB (PTB). On the other hand, anti-TB drugs, like rifampicin and isoniazid have been hypothesised to cause vitamin D deficiency. The objective of this study was to evaluate and compare serum vitamin D status in patients with PTB before and after anti-tuberculosis therapy (ATT).
Methods: A single centre, prospective, observational, double-blinded study was conducted in 50 patients with PTB on category I ATT. Vitamin D samples were collected at baseline, two months and at the end of six months.
Results: The mean age of the study population was 46.7±21.2 years. The mean serum vitamin D level at baseline was 18.1±6.7 ng/mL (Normal > 30ng/mL), 17.9±7.1 ng/mL at two months and, 17.5±7.8 ng/mL at six months. The progressive decline in the mean vitamin D levels was statistically significant (P<0.001). However, it was also observed that in some patients [n=8 (16%)] vitamin D levels increased after ATT; though in majority [n=42 (84%)] vitamin D levels decreased after ATT.
Conclusion: It is postulated that vitamin D supplementation in TB treatment programmes may also have an effect on outcome, thereby the need for further studies to ascertain the exact role, dose and duration of vitamin D augmentation in improving the outcomes.
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