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VOLUME 63 , ISSUE 4 ( October-December, 2021 ) > List of Articles

Indian Guidelines for Diagnosis of Respiratory Allergy

Raj Kumar, D. Behera, A.B. Singh, S.N. Gaur, M.K. Aggarwal, Rajendra Prasad, Balakrishnan Menon, Nitin Goel, Parul Mrigpuri, Sonam Spalgais, P.A. Mahesh, Surya Kant, Ashok Kumar Janmeja, Anant Mohan, V.K. Jain, K.V Nagendra Prasad, Mahesh Goyal, K. Nagaraju, Naveen Arora, Anshu Priya, Kapil Kumar, Rahul Meena, N. Sankararaman, Arvind Kumar Verma, Vatsal Bhushan Gupta, Sonal, Anupam Prakash, M Ahmed Safwan

Citation Information : Kumar R, Behera D, Singh A, Gaur S, Aggarwal M, Prasad R, Menon B, Goel N, Mrigpuri P, Spalgais S, Mahesh P, Kant S, Janmeja AK, Mohan A, Jain V, Prasad KN, Goyal M, Nagaraju K, Arora N, Priya A, Kumar K, Meena R, Sankararaman N, Verma AK, Gupta VB, Sonal, Prakash A, Safwan MA. Indian Guidelines for Diagnosis of Respiratory Allergy. Indian J Chest Dis Allied Sci 2021; 63 (4):223-348.

DOI: 10.5005/ijcdas-63-4-223

License: NA

Published Online: 07-12-2021

Copyright Statement:  NA


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  1. Gupta D, Agarwal R, Aggarwal A, Maturu V, Dhooria S, Prasad K, et al. Guidelines for diagnosis and management of chronic obstructive pulmonary disease: Joint ICS/NCCP (I) recommendations. Lung India 2013;30:228.
  2. Agarwal R, Dhooria S, Aggarwal A, Maturu V, Sehgal I, Muthu V, et al. Guidelines for diagnosis and management of bronchial asthma: Joint ICS/NCCP (I) recommendations. Lung India 2015;32:3.
  3. Navarro AM, Delgado J, Munoz-Cano RM, Dordal MT, Valero A, Quirce S. Allergic respiratory disease (ARD), setting forth the basics: proposals of an expert consensus report. Clin Transl Allergy 2017;7:1.12.
  4. Braunstahl G-J, Kleinjan A, Overbeek SE, Prins J-B, Hoogsteden HC, Fokkens WJ. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med 2000;161:2051.57.
  5. Panzner P, Malkusova I, Vachova M, Li.ka M, Brodska P, Ruz.i.kova O, et al. Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens. Allergol Immunopathol 2015;43:3.9.
  6. Grossman J. One airway, one disease. Chest 1997;111:11S-16S.
  7. Bousquet J, Vignola AM, Demoly P. Links between rhinitis and asthma. Allergy 2003;58:691.706.
  8. Mallol J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A, et al. The International Study of Asthma and Allergies in Childhood (ISAAC) phase three: a global synthesis. Allergol Immunopathol 2013;41:73.85.
  9. Jindal SK, Aggarwal AN, Gupta D, Agarwal R, Kumar R, Kaur T, et al. Indian study on epidemiology of asthma, respiratory symptoms and chronic bronchitis in adults (INSEARCH). Int J Tuberc Lung Dis 2012;16:1270.77.
  10. Krishna MT, Mahesh PA, Vedanthan PK, Mehta V, Moitra S, Christopher DJ. The burden of allergic diseases in the Indian subcontinent: barriers and challenges. Lancet Global Health 2020;8:e478.e479.
  11. Viswanathan R. Definition, incidence, etiology and natural history of asthma. Indian J Chest Dis 1964;6:108.24.
  12. Kumar P, Ram U. Patterns, factors associated and morbidity burden of asthma in India. PloS One 2017;12:e0185938.
  13. Overview of asthma symptoms asthma diagnoses, asthma treatment and asthma. Available at URL: https://www.aaaai. org/conditions-and-treatments/library/asthma-library/asthma-phenotypes#:~:text=Allergic%20asthma%20is%20a%20type,that%20is%20most%20easily%20identified. Accessed on October 30, 2020.
  14. Kim H, Mazza J. Asthma. Allergy Asthma Clin Immunol 2011;7 (Suppl. 1):S2.
  15. Bro.ek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010;126466.76.
  16. Thomas M. Allergic rhinitis: evidence for impact on asthma. BMC Pulm Med 2006;6:1.7.
  17. Singh S, Sharma BB, Salvi S, Chhatwal J, Jain KC, Kumar L, et al. Allergic rhinitis, rhinoconjunctivitis, and eczema: prevalence and associated factors in children. Clin Respir J 2018;12:547.56.
  18. Singh AB. All India Coordinated Project on Aeroallergen and Human. Health Report, Ministry of Environment and Forest 2000.
  19. Jaggi V, Dalal A, Ramesh BR, Tikkiwal S, Chaudhry A, Kothari N, et al. Coexistence of allergic rhinitis and asthma in Indian patients: The CARAS survey. Lung India 2019;36:411.
  20. Martines F, Bentivegna D. Audiological investigation of otitis media in children with atopy. Curr Allergy Asthma Rep 2011;11:513.
  21. Martines F, Martines E, Sciacca V, Bentivegna D. Otitis media with effusion with or without atopy: audiological findings on primary schoolchildren. Am J Otolaryngol 2011;32:601.06.
  22. Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, et al. Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol 2012;129:280.91.
  23. Kidon MI, Chin CW, Kang LW, Ching OT, Seng TY, Ning WK, et al. Mite component.specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspective. Pediatr Allergy Immunol 2011;22:202.10.
  24. Juniper EF, Stahl E, Doty RL, Simons FER, Allen DB, Howarth PH. Clinical outcomes and adverse effect monitoring in allergic rhinitis. J Allergy Clin Immunol 2005;115:S390.S413.
  25. Bousquet J, Bullinger M, Fayol C, Marquis P, Valentin B, Burtin B. Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire. J Allergy Clin Immunol 1994;94:182.8.
  26. Bousquet J, Neukirch F, Bousquet PJ, Gehano P, Klossek JM, Le Gal M, et al. Severity and impairment of allergic rhinitis in patients consulting in primary care. J Allergy Clin Immunol 2006;117:158.62.
  27. Juniper EF, Thompson AK, Ferrie PJ, Roberts JN. Development and validation of the mini Rhinoconjunctivitis Quality of Life Questionnaire: clinical and experimental allergy. J British Society Allergy Clin Immunol 2000;30:132.40.
  28. Deepak D, Shah A. Allergic rhinitis: a neglected disease. Indian J Allergy Appl Immunol 2000;14:6.
  29. Juniper EF. Rhinitis management: the patient's perspective: clinical and experimental allergy. J British Society Allergy Clin Immunol 1998;28:34.38.
  30. Mir E, Panjabi C, Shah A. Impact of allergic rhinitis in school going children. Asia Pacific Allergy 2012;2:93.100.
  31. Behera S. Health outcomes, education, healthcare delivery and quality.3040. Occurrence and effects of nasal polyps in patients with bronchial asthma and/or allergic rhinitis. World Allergy Organ J 2013;6:213.
  32. Marcellusi A, Viti R, Incorvaia C, Mennini FS. Direct and indirect costs associated with respiratory allergic diseases in Italy: a probabilistic cost of illness study. Recenti Prog Med 2015;106:517–27.
  33. Oh H, Koyanagi A, DeVylder JE, Stickley A. Seasonal allergies and psychiatric disorders in the United States. Int J Environ Res Public Health 2018;15:1965.
  34. Martines F, Bentivegna D. Audiological investigation of otitis media in children with atopy. Curr Allergy Asthma Rep 2011;11:513.
  35. Martines F, Martines E, Sciacca V, Bentivegna D. Otitis media with effusion with or without atopy: audiological findings on primary schoolchildren. Am J Otolaryngol 2011;32:601–6.
  36. Bro¿ek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision. J Allergy Clin Immunol 2017;140:950–8.
  37. Warm K, Hedman L, Lindberg A, Lötvall J, Lundbäck B, Rönmark E. Allergic sensitization is age-dependently associated with rhinitis, but less so with asthma. J Allergy Clin Immunol 2015;136:1559–65.
  38. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006;61:376–82.
  39. Geraldo José Cunha Â, Zbonik Mendes A, Dias Wanderley de Carvalho F, Aparecida Ribeiro de Paula M, Gonçalves Brasil T. The impact of asthma on quality of life and anxiety: a pilot study. J Asthma 2019;56:680–5.
  40. Gali K, Šimi J. Study of depression and anxiety in patients with asthma and chronic obstructive pulmonary disease. Psychiat Danubina 2019; 6:6.
  41. Kelly K, Ratliff S, Mezuk B. Allergies, asthma, and psychopathology in a nationally-representative US sample. J Affect Disord 2019;251:130–5.
  42. Thomsen SF. Epidemiology and natural history of atopic diseases. Eur Clin Respir J 2015;2:24642.
  43. Wnuk M, Marcinkowski JT. Jakoœæ¿yciajakopojêciepluralistyczneo charakterzeinterdyscyplinarnym. Problemy Higienyi Epidemiologii 2012;93:21–26.
  44. Mir E. Assessment of health-related quality of life and work productivity in school going children with allergic rhinitis and/or asthma. Dissertation. Delhi: University of Delhi; 2011.
  45. Behera S. Occurrence and effects of nasal polyps in patients with bronchial asthma and/or allergic rhinitis [abstract]. World Allergy Organ J 2013;6(Suppl.1):213.
  46. Jamal D, Shah A. Disturbances in nocturnal sleep, excessive daytime sleepiness and sleep-specific quality of life impairment in patients with allergic rhinitis. World Allergy Organ J 2007;
  47. Oh H, Koyanagi A, DeVylder JE, Stickley A. Seasonal allergies and psychiatric disorders in the United States. Int J Environ Res Public Health 2018;08:15.
  48. Cardell L-O, Olsson P, Andersson M, et al. TOTALL: high cost of allergic rhinitis—a national Swedish population-based questionnaire study. NPJ Prim Care Respir Med 2016;26:15082.
  49. King HC, Mabry RL, Mabry CS, Gordon BR, Marple BF, editors. Interaction with the patient. In: Allergy in ENT Practice: The Basic Guide; 2nd ed. New York: Thieme Medical Publishers; 2005: pp 67–104.
  50. Mims JW. Epidemology of allergic rhinitis. Int Forum Allergy Rhinol 2014;4:18-20.
  51. Sarah J. The history and physical examination of the allergic patient. In: Mahmoudi M, editor. Allergy and Asthma: Practical Diagnosis and Management; 2nd edition. Switzerland: Springer International Publishing; 2016: pp 19-27.
  52. Sataloff‘s. Comprehensive Textbook of Otolaryngology Head and Neck Surgery Series Editor: Robert T Sataloff. VOL. 2 Rhinology/Allergy and Immunology Volume Editors Marvin P Fried, Abtin Tabaee, Jaypee Brothers Medical Publishers; 2016:194-207.
  53. Franzese CB, Burkhalter NW. The patient with allergies. Med Clin North Am 2010;94:891.
  54. Nagaraju K. Allergic rhinitis in children. In: Singh AB, editor Allergy and Allergen Immunotherapy: New Mechanisms and Strategies. 1st edition Apple Academic Press, 2017; pp 309–13.
  55. Usmani O, Barnes PJ. Asthma: clinical presentation and management. In: Fishman‘s Pulmonary Diseases and Disorders; 5th edition. McGraw Hills Education 2015; pp 701–703.
  56. Chhabra N, Houser SM. The surgical management of allergic rhinitis. Otolaryngol Clin North Am 2011;44:779–95.
  57. DeMarcantonio MA, Han JK. Nasal polyps: pathogenesis and treatment implications. Otolaryngol Clin North Am 2011;44:685.
  58. Sih T, Mion O. Allergic rhinitis in the child and associated comorbidities. Pediatr Allergy Immunol 2010;21(1-Part-II): e107–e113.
  59. Woodbury K, Ferguson BJ. Physical findings in allergy. Otolaryngol Clin North Am 2011;44:603–10.
  60. Stachler RJ, Al-khudari S. Differential diagnosis in allergy. Otolaryngol Clin North Am 2011;44:561–90.
  61. Utz VM, Kaufman AR. Allergic eye disease. Pediatr Clin 2014;61:607–20.
  62. Niebuhr M, Werfel T. Innate immunity, allergy and atopic dermatitis. Curr Opin Allergy Clin Immunol 2010;10:463–8.
  63. Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin 2010;30:269–80.
  64. Viegas LP, Ferreira MB, Kaplan AP. The maddening itch: an approach to chronic urticaria. J Investig Allergol Clin Immunol 2014;24:1–5.
  65. Lugogo N, Gque L, Gilstrag DL, Kraft M. Asthma: clinical diagnosis and management. In: Murray & Nadel‘s Textbook of Respiratory Medicine, sixth edition. 2016; pp 732-733.
  66. Lim RH, Kobzik L, Dahl M. Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PloS One 2010;5:e10134.
  67. Becklake MR, Kauffmann F. Gender differences in airway behaviour over the human life span. Thorax 1999;54:1119–38.
  68. Arbes SJ Jr, Gergen PJ, Vaughn B, Zeldin DC. Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 2007;120:1139–45.
  69. Bantz SK, Zhu Z, Zheng T. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. J Clin Cell Immunol 2014;5:202.
  70. Porsbjerg C, von Linstow M-L, Ulrik CS, Nepper-Christensen S, Backer V. Risk factors for onset of asthma: a 12-year prospective follow-up study. Chest 2006;129:309–16.
  71. Do DC, Zhao Y, Gao P. Cockroach allergen exposure and risk of asthma. Allergy 2016;71:463–74.
  72. Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M, et al. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol 2014;134:593–601.
  73. Carlsten C, Brauer M, Dimich-Ward H, Dybuncio A, Becker AB, Chan-Yeung M. Combined exposure to dog and indoor pollution: incident asthma in a high-risk birth cohort. Eur Respir J 2011;37:324–30.
  74. Neuman A, Hohmann C, Orsini N, Pershagen G, Eller E, Kjaer HF, et al. Maternal smoking in pregnancy and asthma in preschool children: a pooled analysis of eight birth cohorts. Am J Respir Crit Care Med 2012;186(10):1037–43.
  75. Devereux G, Turner SW, Craig LC, McNeill G, Martindale S, Harbour PJ, et al. Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. Am J Respir Crit Care Med 2006;174:499– 507.
  76. Litonjua AA, Rifas-Shiman SL, Ly NP, Tantisira KG, Rich-Edwards JW, Camargo Jr CA, et al. Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutri 2006;84:903–11.
  77. Bisgaard H, Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, Schoos A-MM, et al. Fish oil–derived fatty acids in pregnancy and wheeze and asthma in offspring. N Engl J Med 2016;375:2530–9.
  78. Bedard A, Northstone K, Henderson AJ, Shaheen SO. Maternal intake of sugar during pregnancy and childhood respiratory and atopic outcomes. Eur Respir J 2017;50:1700073.
  79. Ku M-S, Sun H-L, Sheu J-N, Lee H-S, Yang S-F, Lue K-H. Neonatal jaundice is a risk factor for childhood asthma: a retrospective cohort study. Pediatr Allergy Immunol 2012;23:623–8.
  80. Stokholm J, Sevelsted A, Anderson UD, Bisgaard H. Preeclampsia associates with asthma, allergy, and eczema in childhood. Am J Respir Crit Care Med 2017;195:614–21.
  81. Tollanes MC, Moster D, Daltveit AK, Irgens LM. Cesarean section and risk of severe childhood asthma: a populationbased cohort study. J Pediatr 2008;153:112–6.
  82. Källén B, Finnström O, Nygren K-G, Olausson PO. Association between preterm birth and intrauterine growth retardation and child asthma. Eur Respir J 2013;41:671–6.
  83. Crump C, Winkleby MA, Sundquist J, Sundquist K. Risk of asthma in young adults who were born preterm: a Swedish national cohort study. Pediatrics 2011;127:e913–e920.
  84. Marra F, Lynd L, Coombes M, Richardson K, Legal M, FitzGerald JM, et al. Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis. Chest 2006;129:610–18.
  85. Sordillo JE, Scirica CV, Rifas-Shiman S, Gillman M, Camargo CA, Weiss ST, et al. Prenatal and infant exposure to analgesics (acetaminophen and ibuprofen) and the risk for asthma-related outcomes. In: b97 early life risk factors for development of asthma. Am Thoracic Soc 2013;A3519.
  86. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ. Mexico City Childhood Asthma Study (MCAAS). Metaanalysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011;43:887–92.
  87. Yunginger JW, Reed CE, O‘Connell EJ, Melton LJ, O‘Fallon WM, Silverstein MD. A community-based study of the epidemiology of asthma. Am Rev Respir Dis 1992;146:888–94.
  88. Galant SP, Morphew T, Amaro S, Liao O. Current asthma guidelines may not identify young children who have experienced significant morbidity. Pediatrics 2006;117:1038–45.
  89. Kuehni CE, Frey U. Age-related differences in perceived asthma control in childhood: guidelines and reality. Eur Respir J 2002;20:880–9.
  90. Castro-Rodriguez JA. The Asthma Predictive Index: a very useful tool for predicting asthma in young children. J Allergy Clin Immunol 2010;126:212–6.
  91. To T, Gershon A, Wang C, Dell S, Cicutto L. Persistence and remission in childhood asthma: a population-based asthma birth cohort study. Arch Pediatr Adolesc Med 2007;161:1197–1204.
  92. Murray C, Foden P, Lowe L, Durrington H, Custovic A, Simpson A. Diagnosis of asthma in symptomatic children based on measures of lung function: ananalysis of data from a population-based birth cohort study. Lancet Child Adolesc Health 2017;1:114–23.
  93. Nair SJ, Daigle KL, DeCuir P, Lapin CD, Schramm CM. The influence of pulmonary function testing on the management of asthma in children. J Pediatr 2005;147:797–801.
  94. Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980–2007. Pediatrics 2009;123(Suppl. 3):S131–S45.
  95. De Marco R, Locatelli F, Sunyer J, Burney P, Group ECRHSS. Differences in incidence of reported asthma related to age in men and women: a retrospective analysis of the data of the European Respiratory Health Survey. Am J Respir Crit Care Med 2000;162:68–74.
  96. de Benedictis D, Bush A. Asthma in adolescence: is there any news? Pediatric Pulmonol 2017;52:129–38.
  97. Burgess JA, Matheson MC, Gurrin LC, Byrnes GB, Adams KS, Wharton CL, et al. Factors influencing asthma remission: a longitudinal study from childhood to middle age. Thorax 2011;66:508–13.
  98. Tai A, Tran H, Roberts M, Clarke N, Gibson A-M, Vidmar S, et al. Outcomes of childhood asthma to the age of 50 years. J Allergy Clin Immunol 2014;133:1572–8.
  99. Strachan DP, Butland BK, Anderson HR. Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort. BMJ 1996;312:1195–9.
  100. Bjerg-Backlund A, Perzanowski MS, Platts-Mills T, Sandstrom T, Lundback B, Ronmark E. Asthma during the primary school ages–prevalence, remission and the impact of allergic sensitization. Allergy 2006;61:549–55
  101. Vonk JM, Boezen HM. Predicting adult asthma in childhood. Curr Opin Pulmon Med 2006;12:42–47.
  102. Masoli M. Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469.78.
  103. Sood A, Qualls C, Schuyler M, Arynchyn A, Alvarado, Smith LJ, et al. Adult-onset asthma becomes the dominant phenotype among women by age 40 years. The longitudinal CARDIA study. Ann Am Thoracic Soc 2013;10:188.197.
  104. Tan DJ, Walters EH, Perret JL, Burgess JA, Johns DP, Lowe AJ, et al. Clinical and functional differences between early-onset and late-onset adult asthma: a population- based Tasmanian Longitudinal Health Study. Thorax 2016;71:981.7.
  105. Ronmark E, Lundback B, Jonsson E, Jonsson A-C, Lindstrom M, Sandstrom T. Incidence of asthma in adults. report from the Obstructive Lung Disease in Northern Sweden Study. Allergy 1997;52:1071.8.
  106. Bronnimann S, Burrows B. A prospective study of the natural history of asthma: remission and relapse rates. Chest 1986;90:480.4.
  107. Maestrelli P. Natural history of adult-onset asthma: insights from model of occupational asthma. Am J Respir Crit Care Med 2004;169:331.2.
  108. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178:218.24.
  109. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010;181:315.23.
  110. Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nature Med 2012;18:716.
  111. Berges-Gimeno MP, Simon RA, Stevenson DD. The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 2002;89:474.8.
  112. Maghni K, Lemiere C, Ghezzo H, Yuquan W, Malo J-L. Airway inflammation after cessation of exposure to agents causing occupational asthma. Am J Respir Crit Care Med 2004;169:367.72.
  113. Greenberger PA. Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 2002;110:685.92.
  114. Miranda C, Busacker A, Balzar S, Trudeau J, Wenzel SE. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 2004;113:101.8.
  115. Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973.84.
  116. Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360:985.93.
  117. Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high- dosage inhaled corticosteroids and long-acting ƒÀ2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet 2016;388(10056):2115.27.
  118. FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, et al. Benralizumab, an anti-interleukin-5 receptor ƒ¿ monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2016;388(10056):2128.41.
  119. Sin DD, Jones RL, Man SP. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med 2002;162:1477.81.
  120. Gunnbjornsdottir MI, Omenaas E, Gislason T, Norrman E, Olin A-C, Jogi R, et al. Obesity and nocturnal gastrooesophageal reflux are related to onset of asthma and respiratory symptoms. Eur Respir J 2004;24:116.21.
  121. Pakhale S, Doucette S, Vandemheen K, Boulet L-P, McIvor RA, FitzGerald JM, et al. A comparison of obese and nonobese people with asthma: exploring an asthma-obesity interaction. Chest 2010;137:1316.23.
  122. Peters-Golden M, Swern A, Bird SS, Hustab CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006;27:495.503.
  123. Jatakanon A. Uasuf C, Maziak W, Lim S, Chung KF, Barnes PJ. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 1999;160:1532.9.
  124. Kato T, Takeda Y, Nakada T, Sendo F. Inhibition by dexamethasone of human neutrophil apoptosis in vitro. Natural Immunity 1995;14:198.208.
  125. Schleimer RP, Freeland HS, Peters SP, Brown KE, Derse CP. An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils. J Pharmacol Exper Therapeu 1989;250:598.605.
  126. Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol 2011;127:153.60.
  127. Gibson PG, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, et al. Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial. Lancet 2017;390(10095):659.68.
  128. Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001.8.
  129. Dahlen S-E, Malmstrom K, Nizankowska EWA, Dahlen B, Kuna P, Kowalski M, et al. Improvement of aspirinintolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med 2002;165:9.14.
  130. Thickett D, Voorham, Ryan J, Jones R, Coker R, Wilson A, et al. Frequency of cough versus dyspnoea as the first recorded symptom of idiopathic pulmonary fibrosis. Eur Respir J 2018;52 (Suppl. 62):OA1651.
  131. Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial. JAMA 2016;315:469.
  132. Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting ƒÀ2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet 2016;388(10039):31.44.
  133. Knutsen AP. Allergic bronchopulmonary aspergillosis in asthma. Expert Rev Clin Immunol 2017;13:11.4.
  134. Agarwal R. Allergic bronchopulmonary aspergillosis. Chest 2009;135:805.26.
  135. Ford ES, Mannino DM, Redd SC, Mokdad AH, Mott JA. Body mass index and asthma incidence among USA adults. Eur Respir J 2004;24:740.4.
  136. Huovinen EK, Koskenvuo M. Factors associated to lifestyle and risk of adult onset asthma. Respir Med 2003;97:273.80.
  137. Nystad W, Meyer HE, Nafstad P, Tverdal A, Engeland A. Body mass index in relation to adult asthma among135,000 Norwegian men and women. Am J Epidemiol 2004;160:969.76.
  138. Jamrozik E, Knuiman MW, James A, Divitini M, Musk AW. Risk factors for adult-onset asthma: a 14-year longitudinal study. Respirology 2009;14:814.21.
  139. Basagana X, Sunyer J, Zock J-P, Kogevinas M, Urrutia I, Maldonado JA, et al. Incidence of asthma and its determinants among adults in Spain. Am J Respir Crit Care Med 2001;164:1133.7.
  140. Almqvist C, Worm M, Leynaert B. Impact of gender on asthma in childhood and adolescence: a GA2LEN review. Allergy 2008;63:47.57.
  141. Jenkins MA, Dharmage SC, Flander LB, Douglass JA, Ugoni AM, Carlin JB, et al. Parity and decreased use of oral contraceptives as predictors of asthma in young women. Clin Exper Allergy 2006;36:609.13.
  142. Dubois P, Degrave E, Vandenplas O. Asthma and airway hyperresponsiveness among Belgian conscripts, 1978-91. Thorax 1998;53:101.5.
  143. Settipane GA, Greisner III WA, Settipane RJ. Natural history of asthma: a 23-year followup of college students. Ann Allergy Asthma Immunol 2000;84:499.503.
  144. Reed CE. The natural history of asthma in adults: the problem of irreversibility. J Allergy Clin Immunol 1999;103:539.47.
  145. Thomas SD, Whitman S. Asthma hospitalizations and mortality in Chicago: an epidemiologic overview. Chest 1999;116:135S-141S.
  146. Kulig M, Klettke U, Wahn V, Forster J, Bauer C-P, Wahn U, et al. Development of seasonal allergic rhinitis during the first 7 years of life. J Allergy Clin Immunol 2000;106:832.39.
  147. Izquierdo-Dominguez A, Jauregui I, del Cuvillo A, Montoro J, Davila I, Sastre J, et al. Allergy rhinitis: similarities and differences between children and adults. Rhinology 2017; 55:326.31.
  148. Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004;113:86.93.
  149. Shaaban R, Zureik M, Soussan D, Anto JM, Heinrich J, Janson C, et al. Allergic rhinitis and onset of bronchial hyperresponsiveness: a population-based study. Am J Respir Crit Care Med 2007;176:659.66.
  150. Rochat MK, Illi S, Ege MJ, Lau S, Keil T, Wahn U, et al. Allergic rhinitis as a predictor for wheezing onset in school-aged children. J Allergy Clin Immunol 2010;126:1170.5.
  151. Patino CM, Martinez FD. Interactions between genes and environment in the development of asthma. Allergy 2001;56:279.86.
  152. Burke W, Fesinmeyer M, Reed K, Hampson L, Carlsten C. Family history as a predictor of asthma risk. Am J Prevent Med 2003;24:160.9.
  153. Paaso EM, Jaakkola MS, Lajunen TK, Hugg TT, Jaakkola JJ. The importance of family history in asthma during the first 27 years of life. Am J Respir Crit Care Med 2013;188:624.6.
  154. Lajunen TK, Jaakkola JJ, Jaakkola MS. Influence of heredity on asthma continues to adulthood. J Allergy Clin Immunol 2013;131:916.8.
  155. Rusconi F, Galassi C, Corbo GM, Forastiere F, Biggeri A, Ciccone G, et al. Risk factors for early, persistent, and lateonset wheezing in young children. Am J Respir Crit Care Med 1999;160:1617.22.
  156. Paaso EM, Jaakkola MS, Rantala AK, Hugg TT, Jaakkola JJ. Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study. Respir Res 2014;15:1.9.
  157. Leung R, Ho P. Asthma, allergy, and atopy in three southeast Asian populations. Thorax 1994;49:1205.10.
  158. Leson S, Gershwin ME. Risk factors for asthmatic patients requiring intubation. I. Observations in children. J Asthma 1995;32:285.94.
  159. Roux P, Smit M, Weinberg EG. Seasonal and recurrent intensive care unit admissions for acute severe asthma in children. South African Med J 1993;83:177.9.
  160. Dold S, Wjst M, von Mutius E, Reitmeir P, Stiepel E. Genetic risk for asthma, allergic rhinitis, and atopic dermatitis. Arch Dis Child 1992;67:1018.22.
  161. Chhabra SK, Gupta CK, Chhabra P, Pal SR. Prevalence of bronchial asthma in schoolchildren in Delhi. J Asthma 1998;35:291.6.
  162. Davoodi P, Mahesh PA, Holla AD, Ramachandra NB. Family history & the risk for adult onset asthma. Indian J Med Res 2015;141:361.
  163. Cheraghi M, Dadgarinejad A, Salvi S. A cross-sectional study to find prevalence and risk factors for childhood asthma in Pune City, India. ISRN Pub Health 2012;2012.
  164. Aggarwal AN, Chaudhry K, Chhabra SK, D Souza GA, Gupta D, Jindal SK, et al. Prevalence and risk factors for bronchial asthma in Indian adults: a multicentre study. Indian J Chest Dis Allied Sci 2006;48:13.
  165. Pokharel PK, Kabra SK, Kapoor SK, Pandey RM. Risk factors associated with bronchial asthma in school going children of rural Haryana. Indian J Pediatr 2001;68:103.6.
  166. Shaikh WA, Shaikh SW. Allergies in India: an analysis of 3389 patients attending an allergy clinic in Mumbai, India. J Indian Med Assoc 2008;106:220.2.
  167. Singh AB, Kumar P. Aeroallergens in clinical practice of allergy in India: an overview. Ann Agri Environ Med 2003;10:131.6.
  168. Braun-Fahrlander C, Gassner M, Grize L, et al. Prevalence of hay fever and allergic sensitization in farmer‘s children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy 1999;29:28–34.
  169. Mutius V. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000;30:1230–4.
  170. Fukuda S, Ishikawa H, Koga Y, Aiba Y, Nakashima K, Cheng L, et al. Allergic symptoms and microflora in school children. J Adolescent Health 2004;35:156–8.
  171. Mahesh PA, Kummeling I, Amrutha DH, Vedanthan PK. Effect of area of residence on patterns of aeroallergen sensitization in atopic patients. Am J Rhinol Allergy 2010;24:e98–e103.
  172. Gupta N, Goyal M, Dixit R, Agrawal M, Meena M, Kuldeep R. Allergen sensitization profile in patients of nasobronchial allergy from rural and urban area of residence in central Rajasthan. J Evid Based Med Health 2018;5:588–92.
  173. Bhattacharya K, Sircar G, Dasgupta A, Bhattacharya SG. Spectrum of allergens and allergen biology in India. Int Arch Allergy Immunol 2018;177:219–37.
  174. Agarwal R, Gupta D. Severe asthma and fungi: current evidence. Med Mycol 2011;49(Suppl.1):S150–S157.
  175. Adhikari A, Sen MM, Gupta-Bhattacharya S, Chanda S. Airborne viable, non-viable, and allergenic fungi in a rural agricultural area of India: a 2-year study at five outdoor sampling stations. Sci Total Environ 2004;326:123–41.
  176. Sánchez-Borges M, Fernandez-Caldas E, Thomas WR, Chapman MD, Lee BW, Caraballo L, et al. International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem. World Allergy Organ J 2017;10:14.
  177. Platts-Mills TA, Vervloet D, Thomas WR, Aalberse RC, Chapman MD. Indoor allergens and asthma: report of the Third International Workshop. J Allergy Clin Immunol 1997;100:S2–S24.
  178. Sampson HA, Muñoz-Furlong A, Bock SA, Schmitt C, Bass R, Chowdhury BA, et al. Symposium on the definition and management of anaphylaxis: summary report. J Allergy Clin Immunol 2005;115:584–91.
  179. Langley SJ, Goldthorpe S, Craven M, Morris J, Woodcock A, Custovic A. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol 2003;112:362–8.
  180. Pomés A, Chapman MD, Wünschmann S. Indoor allergens and allergic respiratory disease. Curr Allergy Asthma Rep 2016;16:43.
  181. Singh AB, Kumar P. Why are my allergies worse indoor? Symptoms, treatment and test kits. Available from URL: https://www.medicenenet.com/indoor_allergens/article. htm. Accessed on September 2, 2021.
  182. Bergmann K-C, Raulffs M, Sander I. House dust mites known to be an allergen source for 50 years: Der p 1 still detectable in the original sample. Allergo J Int 2014;23:320.
  183. Gaur SN. An Indian perspective on dust mites. Indian J Allergy Asthma Immunol 2019;33:14.
  184. Portnoy J, Miller JD, Williams PB, Chew GL, Miller JD, Zaitoun F, et al. Environmental assessment and exposure control of dust mites: a practice parameter. Ann Allergy Asthma Immunol 2013;111:465–507.
  185. Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N England J Med 1997;336:1356–63.
  186. Jeal H, Jones M
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