Citation Information :
Jaggi S, Janmeja AK, Aggarwal D. Role of Pulmonary Rehabilitation in Advanced Non-small Cell Lung Cancer Patients Undergoing Chemotherapy: A Pilot Study. Indian J Chest Dis Allied Sci 2022; 64 (2):94-98.
Background: Patients with advanced lung cancer often suffer from poor mobility and quality-of-life (QoL). Pulmonary rehabilitation (PR) has been seen to improve exercise capacity and health-related QoL (HRQoL) in different respiratory diseases.
Methods: The present study was conducted to evaluate the effect of PR in advanced non-operable non-small cell lung cancer patients on several outcomes compared to the control group. Forty eligible patients were randomized to receive chemotherapy and 8-weeks of supervised, hospital-based PR twice a week (cases) vs only standard chemotherapy (controls). Exercise capacity (6-minute walk distance), HRQoL, Functional Assessment of Cancer Therapy-Lung (FACT-L) scale, spirometry, dyspnea score [modified Medical Research Council (mMRC) grade] and arterial blood gas (ABG) analysis were measured in both the groups at baseline and at the end of 8 weeks.
Results: After PR, there was significant improvement in the 6MWD (change in 6MWD: cases 16.3 + 34.3 m vs controls −20.5 + 49 m; p = 0.03) and total FACT-L score (change in score: cases 18.9 + 7.3 vs controls −8.8 + 13.4; p ≤0.001) in the “cases” group as compared to controls. However, there was no significant improvement in dyspnea, spirometry, and ABG values.
Conclusions: Comprehensive PR can improve exercise capacity and HRQoL in advanced lung cancer patients on concurrent chemotherapy. It may be an integral part of the management of these patients.
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