Aim and background: Lophomonas blattarum, a new flagellate protozoan has been implicated in bronchopulmonary infections. Since the 1990s, reports emerged from peoples Republic of China, followed by reports from other parts of the world too. Six cases have been reported from India so far. To the best of our knowledge, this is the first case report from South India. Case description: A 68-year-old female was hospitalized with symptoms of lower respiratory infection. Computed tomography (CT) thorax showed consolidation with cavitation and centrilobular nodules in the left upper lobe. Sputum Gram, Ziehl–Neilsen stain and bacterial culture did not reveal any etiology. Wet mount of broncho alveolar lavage revealed actively motile organisms with a polar tuft of flagella identified as L. blattarum. She was treated with intravenous metronidazole for a week and oral metronidazole 400 mg thrice daily for the next 3 weeks. The patient was symptomatically better after 2 months of follow-up. Conclusion: Parasites are deterred as a significant etiology of respiratory tract infections, and perception of L. blattarum builds a new element to this assumption. Through this report, we hope to raise awareness among the medical community about this emerging infection and consider it in differential diagnosis in appropriate case settings. Clinical significance: • Lophomonas blattarum is an unconventional and unusual pathogen causing bronchopulmonary infections. • It can be easily missed if not looked for.