The Indian Journal of Chest Diseases and Allied Sciences

Register      Login

VOLUME 62 , ISSUE 3 ( July-September, 2020 ) > List of Articles

Original Article

Survival Analysis of Tuberculosis Patients Registered in a Rural Tuberculosis Unit of Purba Bardhaman District, West Bengal, India

Madhab Chandra Rana, Somnath Naskar, Ramaprasad Roy, Dilip Kumar Das

Keywords : Tuberculosis, Death, Kaplan-Meier survival analysis

Citation Information : Rana MC, Naskar S, Roy R, Das DK. Survival Analysis of Tuberculosis Patients Registered in a Rural Tuberculosis Unit of Purba Bardhaman District, West Bengal, India. Indian J Chest Dis Allied Sci 2020; 62 (3):127-132.

DOI: 10.5005/ijcdas-62-3-127

License: CC BY-NC 4.0

Published Online: 07-11-2022

Copyright Statement:  Copyright © 2020; The Author(s).


Background: India is still a high tuberculosis (TB) burden country in the world and risk factors of the disease are also highly prevalent. Survival analysis of TB patients had not been adequately studied, especially in this part of the country. The present study was undertaken to estimate overall survival time of TB patients and to find out association of different co-variates with outcome event (death) and survival time of TB patients. Methods: A record-based retrospective cohort study was conducted in a Tuberculosis Unit of Purba Bardhaman District, West Bengal, India. All registered TB cases in the unit, excluding resistant cases, between October 2010 to March 2016 were included as study subjects (N=3110) and followed up till June 2017 for outcome of interest. Actual data collection and analysis from relevant registers of the Tuberculosis Unit were carried out during June 2017 to November 2017. Descriptive statistics, Kaplan-Meier survival analysis, Log rank test and Cox proportional hazard model for multivariate analysis were applied. Results: Of 3110 patients, 6.9% (214) had the outcome event of interest (death). The overall mean survival time was 518 days (95% confidence interval 480.9-555.3). Male gender, category II TB, pulmonary TB and TB with human immunodeficiency virus (HIV) were found to be significant risk factors for death due to TB. Conclusions: Overall survival time was significantly low among males, re-treatment cases, patients with pulmonary TB and patients with HIV co-infection. Awareness generation, adherence to treatment, early diagnosis and treatment are some necessary measures to be properly implemented.

PDF Share
  1. World Health Organization. Global TB Report 2017. Available from URL: am/10665/259366/1/9789241565516-eng.pdf?ua=1. Accessed on October 7, 2017.
  2. Park K. Park's Textbook of Preventive and Social Medicine; 24th edition. Jabalpur: Banarsidas Bhanot; 2017.
  3. World Health Organization. Fact-sheet on Tuberculosis. Available from URL: Accessed on December 7, 2017.
  4. World Health Organization. Use of high burden country lists for TB by WHO in the post-2015 era. Available from URL: Accessed on December 7, 2017.
  5. Government of India. Revised National TB Control Programme. Technical and Operational Guidelines for Tuberculosis Control in India, 2016. New Delhi: Ministry of Health and Family Welfare; 2016.
  6. Central TB Division. TB India 2016. Revised National TB Control Programme. Annual Status Report: Unite to End TB. New Delhi: Central TB Division; 2016.
  7. Low S, Ang W, Cutter J, James L, Chee CB, Wang YT, et al. Mortality among tuberculosis patients on treatment in Singapore. Int J Tuberc Lung Dis 2009;13:328–34.
  8. Masini EO, Mansour O, Speer CE, Addona V, Hanson CL, Sitienei JK, et al. Using survival analysis to identify risk factors for treatment interruption among new and retreatment tuberculosis patients in Kenya. PLoS One 2016;11:e0164172.
  9. Santha T, Garg R, Frieden TR, Chandrasekaran V, Subramani R, Gopi PG, et al. Risk factors associated with default, failure and death among tuberculosis patients treated in a DOTS programme in Tiruvallur District, South India. Int J Tuberc Lung Dis 2000;6:780–88.
  10. Senbeta A, Weldegerima G, Romha G. Survival analysis and associated risk factors of tuberculosis in-hospital patients' death in Hawassa city and at Yirgalem town health centers. World J Med Sci 2014;11:382–8.
  11. Pardeshi G. Survival analysis and risk factor for death in tuberculosis patients on Directly Observed Treatment Short-course. Indian J Med Sci 2009;63:180–6.
  12. Ajagbe OB, Kabair Z. Survival analysis of adult tuberculosis disease. PLoS One 2014;11: e112838.
  13. Vasantha M, Gopi PG, Subramani R. Survival of tuberculosis patients treated under DOTS in a rural Tuberculosis Unit (TU), South India. Indian J Tuberc 2008;55:64–69.
  14. Kolappan C, Subramani R, Kumaraswami V, Santha T, Narayanan PR. Excess mortality and risk factors for mortality among a cohort of TB patients from rural South India. Int J Tuberc Lung Dis 2007;12:81–86.
  15. Omari-Sasu AY, Owusu DA, Boateng MA, Sabogu Z. Survival analysis of tuberculosis patients in upper West region of Ghana. Int J Stat Applications 2016;6:40–44
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.