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VOLUME 62 , ISSUE 4 ( October-December, 2020 ) > List of Articles

Original Article

Reliability and Validity of Clinical COPD Questionnaire and Chronic Respiratory Questionnaire in Patients with COPD using Tiotropium Over a Period of 26 Weeks

Gajanan Gaude, Mitchelle Lolly, Jyothi Hattiholi, Bhagyashri Patil

Keywords : COPD, Clinical COPD Questionnaire, Chronic Respiratory Questionnaire, Quality-of-life

Citation Information : Gaude G, Lolly M, Hattiholi J, Patil B. Reliability and Validity of Clinical COPD Questionnaire and Chronic Respiratory Questionnaire in Patients with COPD using Tiotropium Over a Period of 26 Weeks. Indian J Chest Dis Allied Sci 2020; 62 (4):197-201.

DOI: 10.5005/ijcdas-62-4-197

License: NA

Published Online: 07-12-2020

Copyright Statement:  NA


Abstract

Objectives: Patient-centred outcomes, such as health-related quality-of-life (HRQoL) are as important as improvement in the lung function for the optimal management of the patients with chronic obstructive pulmonary disease (COPD). Questionnaires used to assess HRQoL of the patients with COPD should have good reliability, validity and responsiveness. The aim of this study was to investigate and compare the reliability, validity and responsiveness of the Clinical COPD Questionnaire (CCQ) and Chronic Respiratory Questionnaire (CRQ) in patients with mild-to-moderate COPD taking tiotropium. Methods: Seventy-one newly diagnosed patients with mild-to-moderate COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria were included in the study and started on tiotropium (18mcg Transcaps/9mcg metered-dose inhaler), as tiotropium improves the quality-of-life in patients with COPD. Lung function tests were done with a spirometer. The CCQ and CRQ were completed for these patients along with a proforma. Patients were then followed up to 26 weeks with repeat questionnaires and spirometry. Results: Sixty-six patients were analysed as five patients were lost to follow-up. The CCQ was found to be more reliable as compared to CRQ with a Crohnbach's alpha of 0.88. The total score of CCQ and CRQ at baseline were able to discriminate between the GOLD stages making both CCQ and CRQ valid. The CCQ and CRQ were responsive at 8 weeks, 16 weeks and 26 weeks in all domains after the administration of tiotropium as compared to baseline. Conclusions: The CCQ was observed to be more reliable than CRQ. Moreover, the CCQ is easier to administer and interpret compared to CRQ. Therefore, CCQ is better than CRQ for the optimal management of COPD; however, both the questionnaires can be used for future studies involving patients with mild-to-moderate COPD.

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