The Indian Journal of Chest Diseases and Allied Sciences

Register      Login

VOLUME 63 , ISSUE 3 ( July-September, 2021 ) > List of Articles

Original Article

Body Mass Index Association with Airflow Obstruction in Asian Population: A Retrospective Study

Gaurav Gupta, Sanjeev Sinha

Keywords : Body mass index, Chronic obstructive pulmonary disease, Obesity

Citation Information : Gupta G, Sinha S. Body Mass Index Association with Airflow Obstruction in Asian Population: A Retrospective Study. Indian J Chest Dis Allied Sci 2021; 63 (3):125-129.

DOI: 10.5005/ijcdas-63-3-125

License: CC BY-NC 4.0

Published Online: 18-11-2022

Copyright Statement:  Copyright © 2021; The Author(s).


Abstract

Background: The prevalence of chronic obstructive pulmonary disease (COPD) is high in India. Various studies predict better survival in obese COPD patients in comparison to malnourished. The association between the body mass index (BMI) and progression of COPD is still ambiguous and less evaluated. Thus, we aim to determine the impact of different grades of BMI with pulmonary functions. Methods: We studied 294 patients with COPD diagnosed on spirometry on out-patient basis from January 2015 to August 2019. As per BMI the patients were categorised into underweight, normal, overweight and obese. Association between BMI and lung volumes was studied. Results: The number of cases and mean BMI as per BMI grades were: underweight (34 cases, BMI 16.5 Kg/m2), normal weight (76 cases, BMI 21.1 Kg/m2), overweight (27 cases, BMI 24.1 Kg/m2) and obesity (157 cases, BMI 28.2 Kg/m2). With increasing BMI, the value of forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1/FVC ratio were significantly increased. Also, majority of the cases in the obesity group were of low severity as per Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) classification. Conclusion: Our observations suggest that as the BMI increases, lung volumes improve; thus, it may be used as a prognostic indicator for COPD.


PDF Share
  1. MacNee W. Pathology, pathogenesis, and pathophysiology. BMJ 2006;332:1202–4.
  2. Manian P. Chronic obstructive pulmonary disease classification, phenotypes and risk assessment. J Thorac Dis 2019;11(Suppl. 14):S1761–6.
  3. Burden of COPD [Internet]. WHO. [Cited 2020 Mar 29]. Available from URL: https://www.who.int/respiratory/copd/burden/en/. Accessed on March 29, 2020.
  4. Quadric SA, Hurst JR. The unmet global burden of COPD. Glob Health Epidemiol Genomics [Internet]. 2018 Apr 6 [cited 2020 Mar 29]; 3. Available from URL: https://www. ncbi.nlm.nih.gov/pmc/articles/PMC5921960/. Accessed on March 29, 2020.
  5. Salve S, Kumar GA et al. The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990–2016. Lancet Glob Health 2018;6:e1363–74.
  6. Singh V, Sharma BB. Respiratory disease burden in India: Indian chest society SWORD survey. Lung India 2018;35:459–60.
  7. India State-Level Disease Burden Initiative CRD Collaborators. The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990-2016. Lancet Glob Health 2018;6:e1363–74.
  8. Salvi S, Agrawal A. India needs a national COPD prevention and control programme. J Assoc Physicians India 2012;60 (Suppl.):5–7.
  9. Eriksson B, Backman H, Bossios A, Bjerg A, Hedman L, Lindberg A, et al. Only severe COPD is associated with being underweight: results from a population survey. ERJ Open Res 2016;2:00051-2015.
  10. Yamauchi Y, Hasegawa W, Yasunaga H, Sunohara M, Jo T, Takami K, et al. Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan. Int J Chron Obstruct Pulmon Dis 2014; 9:1337–46.
  11. Peters U, Dixon AE. Obesity and asthma. J Allergy Clin Immunol 2018;141:1169–79.
  12. Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 2017;34:70–81.
  13. Mathew JL, Narang I. Sleeping too close together: obesity and obstructive sleep apnea in childhood and adolescence. Paediatr Respir Rev 2014;15:211–8.
  14. From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020. Available from URL: https://goldcopd.org/. Accessed on March 29, 2020.
  15. Aggarwal AN, Agarwal R, Dhooria S, Prasad KT, Sehgal IS, Muthu V, et al. Joint Indian Chest Society- National College of Chest Physicians (India) guidelines for spirometry. Lung India 2019;36:1–35.
  16. Lim JU, Lee JH, Kim JS, Hwang YI, Kim T-H, Lim SY, et al. Comparison of World Health Organization and Asia Pacific body mass index classifications in COPD patients. Int J Chron Obstruct Pulmon Dis 2017;12:2465–7517.
  17. Cao C, Wang R, Wang J, Bunjhoo H, Xu Y, Xiong W. Body mass index and mortality in chronic obstructive pulmonary disease: a meta-analysis. PLoS One 2012;7:8.
  18. Liu XM, Liu YJ, Zhan J, He QQ. Overweight, obesity and risk of all-cause and cardiovascular mortality in patients with type 2 diabetes mellitus: a dose–response metaanalysis of prospective cohort studies. Eur J Epidemiol 2014; 30:35–45.
  19. Bagheri M, Speakman JR, Shabbidar S, Kazemi F, Djafarian K. A dose–response meta-analysis of the impact of body mass index on stroke and all-causemortality in stroke patients: a paradox within a paradox. Obese Rev 2015;16:41623.
  20. Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis. Am J Kidney Dis 2007;49:581–91.
  21. Galesanu RG, Bernard S, Marquis K, Lacasse Y, Poirier P, Bourbeau J, et al. Obesity and chronic obstructive pulmonary disease: is fatter really better? Canadian Respir J 2014;21:297–301.
  22. Marquis K, Debugger R, Lacasse Y, LeBlanc P, Jobin J, Carrier G, et al. Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166:809–13.
  23. Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, et al. Obesity is associated with increased morbidity in moderate to severe COPD. Chest 2017;151:68–77.
  24. Wu Z, Yang D, Ge Z, Yan M, Wu N, Liu Y. Body mass index of patients with chronic obstructive pulmonary disease is associated with pulmonary function and exacerbations: a retrospective real world research. J Thorac Dis 2018;10:5086–509.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.