The Indian Journal of Chest Diseases and Allied Sciences

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VOLUME 60 , ISSUE 4 ( October-December, 2018 ) > List of Articles


Lymphoepithelioma-like Carcinoma of Lung: An Important Albeit Uncommon Diagnosis

Gourahari Pradhan, Sourin Bhuniya, Susama Patra, Nibedita Sahoo

Keywords : Lymphoepithelioma, Epstein-Barr virus, Carcinoma, Lung

Citation Information : Pradhan G, Bhuniya S, Patra S, Sahoo N. Lymphoepithelioma-like Carcinoma of Lung: An Important Albeit Uncommon Diagnosis. Indian J Chest Dis Allied Sci 2018; 60 (4):249-252.

DOI: 10.5005/ijcdas-60-4-249

License: CC BY-NC 4.0

Published Online: 18-11-2022

Copyright Statement:  Copyright © 2018; The Author(s).


A 25-year-old young male presented with pain in chest and left shoulder for two months, dry cough, shortness of breath for one month and hoarseness of voice for 15 days. He was a non-smoker and served in the armed forces. Chest radiograph showed homogeneous opacity over the entire left hemithorax obliterating left costophrenic and cardiophrenic angles with a shift of mediastinum to the contralateral side. Contrast-enhanced computed tomography of chest and upper abdomen revealed a large mass lesion involving left upper lobe with minimal pleural effusion on the left. Bronchial washing cytology was positive for malignant cells. Endobronchial biopsy showed clusters, nests and small island of tumour cells infiltrating bronchial mucosa. Immunohistochemistry was focal positive for CK 5/6 and synaptophysin, strongly positive for pancytokeratin and Epstein-Barr virus, negative for thyroid transcription factor (TTF1) and CD 68; human leucocyte common antigen taken up by accompanying lymphoid cells confirmed the diagnosis of lymphoepithelioma like carcinoma. This variety of lung cancer is very rare, occurs mostly in Asians and has relatively better prognosis compared to non-small cell carcinomas. In young adults with lung mass; possibility of this uncommon variety of malignancy is high with a favourable outcome if diagnosed early and needs an aggressive clinical work-up.

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