Citation Information :
Dharani M, Desai U, Joshi J, Bharmal RN. Clinical Profile of Connective Tissue Disease- related Interstitial Lung Diseases at a Tertiary Care Center in Western India. Indian J Chest Dis Allied Sci 2022; 64 (4):311-313.
Connective tissue disorders (CTDs) are one of the common causes of interstitial lung diseases (ILDs). This prospective observational study included around 51 patients of CTD-ILDs, and their demographic, clinical, radiological, and laboratory profiles were studied. The most common type of CTD-ILD in our study is rheumatoid arthritis-related ILD. On high-resolution computed tomography (HRCT) thorax, nonspecific interstitial pneumonia (NSIP) was the most common pattern seen in 30 patients (59%), followed by usual interstitial pneumonia (UIP) seen in 20 patients (39%). Even though CTD-ILDs are similar to other idiopathic ILDs in clinical and radiological presentation, patients with CTDs have to be evaluated clinically and radiologically for early diagnosis. Early treatment initiation and pulmonary rehabilitation help in delaying the progression of disease. Among all ILDs, CTD-ILDs are associated with better prognosis and survival.
Furukawa H, Oka S, Shimada K, et al. Autoantibody profiles in collagen disease patients with interstitial lung disease (ILD): Antibodies to major histocompatibility complex class I-related chain A (MICA) as markers of ILD. Biomark Insights 2015;10:63–73. DOI: 10.4137/BMI.S28209.
Isabel FP, Zab M. Interstitial lung disease associated with collagen vascular disease. Medscape, updated on Sep 20, 2013. Available at: http://emedicine.medscape.com/article/1343513-over view.
Self SE. Autoantibody testing for autoimmune disease. Clin Chest Med 2010;31(3):415–422. DOI: 10.1016/j.ccm.2010.04.001.
Strange C, Highland KB. Interstitial lung disease in the patient who has connective tissue disease. Clin Chest Med 2004;25(3):549–559. DOI: 10.1016/j.ccm.2004.05.009.
Fischer A, West SG, Swigris JJ, et al. Connective tissue disease-associated interstitial lung disease: A call for clarification. Chest 2010;138(2):251–256. DOI: 10.1378/chest.10-0194.
Lee H, Kim DS, Yoo B, et al. Histopathologic pattern and clinical features of rheumatoid arthritis associated interstitial lung disease. Chest 2005;127(6):2019–2027. DOI: 10.1378/chest.127.6.2019.
Gutsche M, Rosen GD, Swigris JJ. Connective tissue disease-associated interstitial lung disease: A review. Curr Respir Care Rep 2012;1: 224–232. DOI: 10.1007/s13665-012-0028-7.
Tanaka N, Kim JS, Newell JD, et al. Rheumatoid arthritis-related lung diseases: CT findings description of characteristic HRCT patterns in patients with RA-related ILD. Radiology 2004;232(1):81–91. DOI: 10.1148/radiol.2321030174.
Parambil JG, Myers JL, Ryu JH. Diffuse alveolar damage: Uncommon manifestation of pulmonary involvement in patients with connective tissue diseases. Chest 2006;130(2):553–558. DOI: 10.1378/chest.130.2.553.
Muir TE, Tazelaar HD, Colby TV, et al. Organizing diffuse alveolar damage associated with progressive systemic sclerosis. Mayo Clin Proc 1997;72(7):639–642. DOI: 10.1016/S0025-6196(11)63569-6.
Phillips K, Byrne-Dugan C, Batterson E, et al. Rapidly progressive fatal interstitial lung disease in a patient with systemic sclerosis. Nat Rev Rheumatol 2009;5(4):225–228. DOI: 10.1038/nrrheum.2009.30.
Castagnaro A, Chetta A, Marangio E, et al. The lung in immune mediated disorder: Rheumatoid arthritis. Curr Drug Targets Inflamm Allergy 2004;3(4):449–454. DOI: 10.2174/1568010042634532.
Olson AL, Swigris JJ. Idiopathic pulmonary fibrosis: Diagnosis and epidemiology. Clin Chest Med 2012;33(1):41–50. DOI: 10.1016/j.ccm.2011.12.001.
Spagnolo P, Cordier J-F, Cottin V. Connective tissue diseases, multimorbidity and the ageing lung. Eur Respir J 20167(5):1535–1558. DOI: 10.1183/13993003.00829-2015.
Larsen BT, Smith ML, Elicker BM, et al. Diagnostic approach to advanced fibrotic interstitial lung disease: Bringing together clinical, radiologic, and histologic clues. Arch Pathol Lab Med 2016;141(7): 901–915. DOI: 10.5858/arpa.2016-0299-SA.
Thomeer MJ, Vansteenkiste J, Verbeken EK, et al. Interstitial lung diseases: Characteristics at diagnosis and mortality risk assessment. Respir Med 2004;98(6):567–573. DOI: 10.1016/j.rmed.2003.10.015.
Takeda A, Ishii Y. Interstitial pneumonia associated with connective tissue disease: A comprehensive overview and an insight into the pathogenesis. Contemp Top Pneumonia 2017;20:145. DOI: 10.5772/intechopen.70864.
Antin-Ozerkis D, Rubinowitz A, Evans J, et al. Interstitial lung disease in the connective tissue diseases. Clin Chest Med 2012;33(1):123–149. DOI: 10.1016/j.ccm.2012.01.004.
Singh S, Collins BF, Sharma BB, et al. Interstitial lung disease in India: Results of a prospective registry. Am J Respir Crit Care Med 2017;195(6):801–813. DOI: 10.1164/rccm.201607-1484OC.
Mittoo S, Gelber AC, Christopher-Stine L, et al. Ascertainment of collagen vascular disease in patients presenting with interstitial lung disease. Respir Med 2009;103(8):1152–1158. DOI: 10.1016/j.rmed. 2009.02.009.
Molina-Molina M, Badia JR, Marín-Arguedas A, et al. Outcomes and clinical characteristics of patients with pulmonary fibrosis and respiratory failure admitted to an intensive care unit. A study of 20 cases. Med Clin 2003;121(2):63–67. PMID: 10.1016/s0025-7753(03) 73856-1.
Das V, Desai U, Joshi JM. Clinical profile of interstitial lung disease at a tertiary care centre, India. Pneumon 2017;30(1):17–23.
AbouYoussef HA, Sabri YYY, El Essawy AF, et al. Clinico-radiography and pulmonary functional assessment of patients with diffuse parenchymal lung diseases in al-fayoum governorate. Egypt J Bronchol 2019;13(1):125. DOI: 10.4103/ejb.ejb_40_18.
Omar MM, Alhalafawy AS, Emara NM, et al. The role of medical thoracoscopic lung biopsy in diagnosis of diffuse parenchymal lung diseases. Egypt J Bronchol 2019;13(2):155–161. DOI: 10.4103/ejb.ejb_41_18.
Wallace B, Vummidi D, Khanna D. Management of connective tissue diseases associated interstitial lung disease: A review of the published literature. Curr Opin Rheumatol 2016;28(3):236–245. DOI: 10.1097/BOR.0000000000000270.
Frank AL, Kreuter M, Schwarzkopf L. Economic burden of incident interstitial lung disease (ILD) and the impact of comorbidity on costs of care. Respir Med 2019;152:25–31. DOI: 10.1016/j.rmed.2019.04.009.