Background: Coronavirus disease-2019 (COVID-19) has emerged as the most dreadful pandemic the world has ever witnessed. The disease spectrum can range anywhere from a mild asymptomatic form to conditions leading to acute respiratory distress syndrome (ARDS). Earlier assessment of severity using inflammatory markers may influence the prognosis in patients.
Objective: This study was done to evaluate the association between the clinical characteristics, inflammatory markers, and computed tomography (CT) severity scores in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: This retrospective, single-center study consisted of 428 consecutive hospitalized patients with confirmed COVID-19 from 1 August 2020 to 28 December 2020. Clinical characteristics, demographics, CT results, and levels of inflammatory markers of patients, were recorded and analyzed and correlations were done using available biostatistical tools.
Results: The computed tomography severity score (CTSS) had a strong positive correlation with C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), and neutrophil-to-lymphocyte ratio (NLR). A negative correlation of CTSS was found with the absolute lymphocyte count (ALC). There was also a significant correlation between hemoglobin A1C (HbA1C) levels and the CTSS.
Conclusion: The COVID-19 infection can cause a severe inflammatory response which may lead to systemic manifestations along with pneumonia. In resource-limited settings, early measurement of inflammatory markers can obviate the need for CT scans and aid in assessing prognosis and subsequent management.
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